Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia
Essential thrombocythemia (ET) occurs predominantly in the elderly, but approximately 20% of patients are <40 years old. Unlike other myeloproliferative neoplasms, ET occurs more commonly in women. We encountered a 38-year-old women diagnosed with ET who exhibited elevated platelet count in early...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2021/6633790 |
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| author | Yoshinori Hashimoto Rina Hosoda Hiromi Omura Takayuki Tanaka |
| author_facet | Yoshinori Hashimoto Rina Hosoda Hiromi Omura Takayuki Tanaka |
| author_sort | Yoshinori Hashimoto |
| collection | DOAJ |
| description | Essential thrombocythemia (ET) occurs predominantly in the elderly, but approximately 20% of patients are <40 years old. Unlike other myeloproliferative neoplasms, ET occurs more commonly in women. We encountered a 38-year-old women diagnosed with ET who exhibited elevated platelet count in early pregnancy. Her platelet count exceeded 1500 × 109/L by late pregnancy; interferon α was administered but failed to induce an adequate response. She underwent emergency cesarean delivery at 37 weeks of gestation. Although her platelet count was 1000 × 109/L immediately after delivery, it markedly increased to 3271 × 109/L approximately 2 weeks later. Cytoreductive therapy was resumed; the subsequent course was free from complications. Several review articles have indicated that because platelet counts of patients may again increase to the pregnancy level or rebound after delivery, cytoreductive therapy should be administered if necessary. However, there is insufficient information on when therapeutic interventions are necessary and how they should be performed. It remains unknown whether the platelet count will decrease after some time without treatment if it rebounds. We hope management guidelines will be established by collecting detailed data on the postpartum course as well as during pregnancy. |
| format | Article |
| id | doaj-art-674f599ecf69405db9b22a4c9c2fe4bd |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-674f599ecf69405db9b22a4c9c2fe4bd2025-02-03T06:43:34ZengWileyCase Reports in Hematology2090-65602090-65792021-01-01202110.1155/2021/66337906633790Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential ThrombocythemiaYoshinori Hashimoto0Rina Hosoda1Hiromi Omura2Takayuki Tanaka3Department of Hematology, Tottori Prefectural Central Hospital, Tottori, JapanDepartment of Hematology, Tottori Prefectural Central Hospital, Tottori, JapanDepartment of Hematology, Tottori Prefectural Central Hospital, Tottori, JapanDepartment of Hematology, Tottori Prefectural Central Hospital, Tottori, JapanEssential thrombocythemia (ET) occurs predominantly in the elderly, but approximately 20% of patients are <40 years old. Unlike other myeloproliferative neoplasms, ET occurs more commonly in women. We encountered a 38-year-old women diagnosed with ET who exhibited elevated platelet count in early pregnancy. Her platelet count exceeded 1500 × 109/L by late pregnancy; interferon α was administered but failed to induce an adequate response. She underwent emergency cesarean delivery at 37 weeks of gestation. Although her platelet count was 1000 × 109/L immediately after delivery, it markedly increased to 3271 × 109/L approximately 2 weeks later. Cytoreductive therapy was resumed; the subsequent course was free from complications. Several review articles have indicated that because platelet counts of patients may again increase to the pregnancy level or rebound after delivery, cytoreductive therapy should be administered if necessary. However, there is insufficient information on when therapeutic interventions are necessary and how they should be performed. It remains unknown whether the platelet count will decrease after some time without treatment if it rebounds. We hope management guidelines will be established by collecting detailed data on the postpartum course as well as during pregnancy.http://dx.doi.org/10.1155/2021/6633790 |
| spellingShingle | Yoshinori Hashimoto Rina Hosoda Hiromi Omura Takayuki Tanaka Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia Case Reports in Hematology |
| title | Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia |
| title_full | Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia |
| title_fullStr | Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia |
| title_full_unstemmed | Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia |
| title_short | Marked Rebound of Platelet Count in the Early Postpartum Period in a Patient with Essential Thrombocythemia |
| title_sort | marked rebound of platelet count in the early postpartum period in a patient with essential thrombocythemia |
| url | http://dx.doi.org/10.1155/2021/6633790 |
| work_keys_str_mv | AT yoshinorihashimoto markedreboundofplateletcountintheearlypostpartumperiodinapatientwithessentialthrombocythemia AT rinahosoda markedreboundofplateletcountintheearlypostpartumperiodinapatientwithessentialthrombocythemia AT hiromiomura markedreboundofplateletcountintheearlypostpartumperiodinapatientwithessentialthrombocythemia AT takayukitanaka markedreboundofplateletcountintheearlypostpartumperiodinapatientwithessentialthrombocythemia |