Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic man...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/9246596 |
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| _version_ | 1832551879718993920 |
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| author | Jeremy Chuang An Uche Rohan Gupta Kim Margolin Phyllis Kim |
| author_facet | Jeremy Chuang An Uche Rohan Gupta Kim Margolin Phyllis Kim |
| author_sort | Jeremy Chuang |
| collection | DOAJ |
| description | Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic manifestations and discuss the patient’s brief response to combination therapy. In our discussion, we highlight the current understanding of DIC and also identify opportunities for future research to elucidate the genetic aberrations in melanoma that may result in treatment resistance to combination therapy. |
| format | Article |
| id | doaj-art-674bac8a94914f2abc00293694253f45 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-674bac8a94914f2abc00293694253f452025-02-03T06:00:15ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/92465969246596Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated MelanomaJeremy Chuang0An Uche1Rohan Gupta2Kim Margolin3Phyllis Kim4Department of Internal Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USADivision of Hematology and Medical Oncology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USADivision of Hematology and Medical Oncology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USADepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USADivision of Hematology and Medical Oncology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USAAcute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic manifestations and discuss the patient’s brief response to combination therapy. In our discussion, we highlight the current understanding of DIC and also identify opportunities for future research to elucidate the genetic aberrations in melanoma that may result in treatment resistance to combination therapy.http://dx.doi.org/10.1155/2019/9246596 |
| spellingShingle | Jeremy Chuang An Uche Rohan Gupta Kim Margolin Phyllis Kim Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma Case Reports in Oncological Medicine |
| title | Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma |
| title_full | Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma |
| title_fullStr | Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma |
| title_full_unstemmed | Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma |
| title_short | Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma |
| title_sort | fulminant disseminated intravascular coagulation as initial presentation of braf mutated melanoma |
| url | http://dx.doi.org/10.1155/2019/9246596 |
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