Lipid Chaperones and Metabolic Inflammation

Over the past decade, a large body of evidence has emerged demonstrating an integration of metabolic and immune response pathways. It is now clear that obesity and associated disorders such as insulin resistance and type 2 diabetes are associated with a metabolically driven, low-grade, chronic infla...

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Main Authors: Masato Furuhashi, Shutaro Ishimura, Hideki Ota, Tetsuji Miura
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.4061/2011/642612
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author Masato Furuhashi
Shutaro Ishimura
Hideki Ota
Tetsuji Miura
author_facet Masato Furuhashi
Shutaro Ishimura
Hideki Ota
Tetsuji Miura
author_sort Masato Furuhashi
collection DOAJ
description Over the past decade, a large body of evidence has emerged demonstrating an integration of metabolic and immune response pathways. It is now clear that obesity and associated disorders such as insulin resistance and type 2 diabetes are associated with a metabolically driven, low-grade, chronic inflammatory state, referred to as “metaflammation.” Several inflammatory cytokines as well as lipids and metabolic stress pathways can activate metaflammation, which targets metabolically critical organs and tissues including adipocytes and macrophages to adversely affect systemic homeostasis. On the other hand, inside the cell, fatty acid-binding proteins (FABPs), a family of lipid chaperones, as well as endoplasmic reticulum (ER) stress, and reactive oxygen species derived from mitochondria play significant roles in promotion of metabolically triggered inflammation. Here, we discuss the molecular and cellular basis of the roles of FABPs, especially FABP4 and FABP5, in metaflammation and related diseases including obesity, diabetes, and atherosclerosis.
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spelling doaj-art-6730c06a7aa54b03913d07c4974f2cc32025-02-03T05:58:34ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/642612642612Lipid Chaperones and Metabolic InflammationMasato Furuhashi0Shutaro Ishimura1Hideki Ota2Tetsuji Miura3Second Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, JapanSecond Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, JapanSecond Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, JapanSecond Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, JapanOver the past decade, a large body of evidence has emerged demonstrating an integration of metabolic and immune response pathways. It is now clear that obesity and associated disorders such as insulin resistance and type 2 diabetes are associated with a metabolically driven, low-grade, chronic inflammatory state, referred to as “metaflammation.” Several inflammatory cytokines as well as lipids and metabolic stress pathways can activate metaflammation, which targets metabolically critical organs and tissues including adipocytes and macrophages to adversely affect systemic homeostasis. On the other hand, inside the cell, fatty acid-binding proteins (FABPs), a family of lipid chaperones, as well as endoplasmic reticulum (ER) stress, and reactive oxygen species derived from mitochondria play significant roles in promotion of metabolically triggered inflammation. Here, we discuss the molecular and cellular basis of the roles of FABPs, especially FABP4 and FABP5, in metaflammation and related diseases including obesity, diabetes, and atherosclerosis.http://dx.doi.org/10.4061/2011/642612
spellingShingle Masato Furuhashi
Shutaro Ishimura
Hideki Ota
Tetsuji Miura
Lipid Chaperones and Metabolic Inflammation
International Journal of Inflammation
title Lipid Chaperones and Metabolic Inflammation
title_full Lipid Chaperones and Metabolic Inflammation
title_fullStr Lipid Chaperones and Metabolic Inflammation
title_full_unstemmed Lipid Chaperones and Metabolic Inflammation
title_short Lipid Chaperones and Metabolic Inflammation
title_sort lipid chaperones and metabolic inflammation
url http://dx.doi.org/10.4061/2011/642612
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