Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018
BackgroundElderly individuals with inadequate vitamin B level are at increased risk of degenerative conditions, notably cardiovascular disorders, cognitive impairments, and osteoporosis. The relationship between niacin (vitamin B3) consumption and osteoporosis risk remains a subject of debate. This...
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Frontiers Media S.A.
2025-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1504892/full |
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| author | Li Li Wankun Liang Bing Deng Yue Jiang Xiaomin Huang Yanlin Zhang Tianrui Lu Lu Wang Yunxiang Xu Guizhen Chen |
| author_facet | Li Li Wankun Liang Bing Deng Yue Jiang Xiaomin Huang Yanlin Zhang Tianrui Lu Lu Wang Yunxiang Xu Guizhen Chen |
| author_sort | Li Li |
| collection | DOAJ |
| description | BackgroundElderly individuals with inadequate vitamin B level are at increased risk of degenerative conditions, notably cardiovascular disorders, cognitive impairments, and osteoporosis. The relationship between niacin (vitamin B3) consumption and osteoporosis risk remains a subject of debate. This study aimed to clarify the relationship between dietary niacin intake and the incidence of osteoporosis in postmenopausal women aged ≥50 years.MethodsIn this study, we gathered details on participants’ bone mineral density, osteoporosis status, dietary niacin intake, and several other critical variables. Multivariate logistic regression models were constructed to determine the association between dietary niacin intake and the incidence of osteoporosis. Restricted cubic splines were employed to further assess the linearity and explore the shape of the dose-response associations. Additionally, we performed stratified and interaction analyses to illustrate the stability of the observed relationships across different subgroups.ResultsAfter adjusting for all covariates, there was a significant inverse association with osteoporosis (OR = 0.87; 95% CI: 0.77–0.97; p = 0.016). A negative relationship was observed between dietary niacin intake and the risk of osteoporosis (nonlinear: p = 0.672). While stratified analyses revealed some differences in the association between dietary niacin intake and osteoporosis risk, these differences were not statistically significant.ConclusionDietary niacin intake exhibited an inverse correlation with the incidence of osteoporosis. The risk of osteoporosis was significantly reduced by 13% with every 10 mg/day increase in daily dietary niacin consumption among postmenopausal women. |
| format | Article |
| id | doaj-art-672d9a02911e485f9d746ddb6792565c |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-672d9a02911e485f9d746ddb6792565c2025-02-05T07:32:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15048921504892Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018Li Li0Wankun Liang1Bing Deng2Yue Jiang3Xiaomin Huang4Yanlin Zhang5Tianrui Lu6Lu Wang7Yunxiang Xu8Guizhen Chen9The Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaClinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, ChinaClinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaThe Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaClinical Medical College of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Seventh Clinical College of Guangzhou University of Chinese Medicine, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, ChinaBackgroundElderly individuals with inadequate vitamin B level are at increased risk of degenerative conditions, notably cardiovascular disorders, cognitive impairments, and osteoporosis. The relationship between niacin (vitamin B3) consumption and osteoporosis risk remains a subject of debate. This study aimed to clarify the relationship between dietary niacin intake and the incidence of osteoporosis in postmenopausal women aged ≥50 years.MethodsIn this study, we gathered details on participants’ bone mineral density, osteoporosis status, dietary niacin intake, and several other critical variables. Multivariate logistic regression models were constructed to determine the association between dietary niacin intake and the incidence of osteoporosis. Restricted cubic splines were employed to further assess the linearity and explore the shape of the dose-response associations. Additionally, we performed stratified and interaction analyses to illustrate the stability of the observed relationships across different subgroups.ResultsAfter adjusting for all covariates, there was a significant inverse association with osteoporosis (OR = 0.87; 95% CI: 0.77–0.97; p = 0.016). A negative relationship was observed between dietary niacin intake and the risk of osteoporosis (nonlinear: p = 0.672). While stratified analyses revealed some differences in the association between dietary niacin intake and osteoporosis risk, these differences were not statistically significant.ConclusionDietary niacin intake exhibited an inverse correlation with the incidence of osteoporosis. The risk of osteoporosis was significantly reduced by 13% with every 10 mg/day increase in daily dietary niacin consumption among postmenopausal women.https://www.frontiersin.org/articles/10.3389/fmed.2025.1504892/fullniacin intakeosteoporosisbone healthpostmenopausal womenNHANES |
| spellingShingle | Li Li Wankun Liang Bing Deng Yue Jiang Xiaomin Huang Yanlin Zhang Tianrui Lu Lu Wang Yunxiang Xu Guizhen Chen Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018 Frontiers in Medicine niacin intake osteoporosis bone health postmenopausal women NHANES |
| title | Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018 |
| title_full | Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018 |
| title_fullStr | Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018 |
| title_full_unstemmed | Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018 |
| title_short | Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018 |
| title_sort | association of dietary niacin intake with osteoporosis in the postmenopausal women in the us nhanes 2007 2018 |
| topic | niacin intake osteoporosis bone health postmenopausal women NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1504892/full |
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