Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration

Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration

Abstract Low back pain caused by intervertebral disc degeneration (IDD) has emerged as a significant global public health concern, with far-reaching consequences for patients' quality of life and healthcare systems. Although previous research have revealed that the mechanisms of intervertebral...

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Bibliographic Details
Main Authors: Heng Chen, Tian Tang, Congyang Xue, Xin Liu, Zhipeng Xi, Lin Xie, Ran Kang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Intervertebral disc degeneration
Cell death mode
Apoptosis
Pyroptosis
Necroptosis
Cell senescence
Online Access:https://doi.org/10.1186/s13018-024-05280-z
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