Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet
Obesity is affecting global health with multiple complications, including cardiac dysfunction. Currently, it is uncertain whether drug therapy should be applied in the early stages of obesity-induced cardiac dysfunction, with weight reduction as the first choice. Sleeve gastrectomy (SG) has been wid...
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The Japan Endocrine Society
2024-05-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/5/71_EJ23-0567/_html/-char/en |
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| author | Xiaojuan Li Luming Qiao Wei Wang Ying Shi Lei Yuan Zhiwei Zhai |
| author_facet | Xiaojuan Li Luming Qiao Wei Wang Ying Shi Lei Yuan Zhiwei Zhai |
| author_sort | Xiaojuan Li |
| collection | DOAJ |
| description | Obesity is affecting global health with multiple complications, including cardiac dysfunction. Currently, it is uncertain whether drug therapy should be applied in the early stages of obesity-induced cardiac dysfunction, with weight reduction as the first choice. Sleeve gastrectomy (SG) has been widely used to treat obesity and its complications, showing promising results. However, it remains unclear whether SG can alleviate obesity-induced cardiac dysfunction. A sudden decline in body weight and food intake was observed in both the obese and obese + SG groups, with a higher rate of increase observed in the Obese group. Elevated levels of plasma glucose, serum insulin, and glycated haemoglobin in obese rats were significantly reduced by SG. Markedly increased levels of alanine transaminase, aspartate transaminase, alkaline phosphatase albumin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, elevated values of heart rate, left ventricular end-systolic pressure, left ventricular end-diastolic pressure, systolic pressure, and end diastolic pressure, and decreased value of stroke volume were observed in obese rats, which were sharply reversed by SG. Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. Lastly, the increased levels of relative proteins observed in obese rats were significantly reduced by SG. In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet. |
| format | Article |
| id | doaj-art-671d8325522546119a3d7beaa879f231 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-671d8325522546119a3d7beaa879f2312025-01-22T06:39:10ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-05-0171552753610.1507/endocrj.EJ23-0567endocrjSleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar dietXiaojuan Li0Luming Qiao1Wei Wang2Ying Shi3Lei Yuan4Zhiwei Zhai5Department of Endocrinology, Laizhou People’s Hospital, Laizhou 261400, Shandong Province, ChinaDepartment of Laboratory Medicine, Laizhou People’s Hospital, Laizhou 261400, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Laizhou People’s Hospital, Laizhou 261400, Shandong Province, ChinaDepartment of Reproductive Medicine, Laizhou People’s Hospital, Laizhou 261400, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Laizhou People’s Hospital, Laizhou 261400, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Laizhou People’s Hospital, Laizhou 261400, Shandong Province, ChinaObesity is affecting global health with multiple complications, including cardiac dysfunction. Currently, it is uncertain whether drug therapy should be applied in the early stages of obesity-induced cardiac dysfunction, with weight reduction as the first choice. Sleeve gastrectomy (SG) has been widely used to treat obesity and its complications, showing promising results. However, it remains unclear whether SG can alleviate obesity-induced cardiac dysfunction. A sudden decline in body weight and food intake was observed in both the obese and obese + SG groups, with a higher rate of increase observed in the Obese group. Elevated levels of plasma glucose, serum insulin, and glycated haemoglobin in obese rats were significantly reduced by SG. Markedly increased levels of alanine transaminase, aspartate transaminase, alkaline phosphatase albumin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, elevated values of heart rate, left ventricular end-systolic pressure, left ventricular end-diastolic pressure, systolic pressure, and end diastolic pressure, and decreased value of stroke volume were observed in obese rats, which were sharply reversed by SG. Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. Lastly, the increased levels of relative proteins observed in obese rats were significantly reduced by SG. In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet.https://www.jstage.jst.go.jp/article/endocrj/71/5/71_EJ23-0567/_html/-char/ensleeve gastrectomyobesitycardiac dysfunctionlipid metabolism disorder |
| spellingShingle | Xiaojuan Li Luming Qiao Wei Wang Ying Shi Lei Yuan Zhiwei Zhai Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet Endocrine Journal sleeve gastrectomy obesity cardiac dysfunction lipid metabolism disorder |
| title | Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet |
| title_full | Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet |
| title_fullStr | Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet |
| title_full_unstemmed | Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet |
| title_short | Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet |
| title_sort | sleeve gastrectomy improves cardiac function and glucose lipid metabolism disorder in obese rats induced by a high fat and high sugar diet |
| topic | sleeve gastrectomy obesity cardiac dysfunction lipid metabolism disorder |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/5/71_EJ23-0567/_html/-char/en |
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