Propolis – quality analysis and use in topical formulations
The aim of this study was to produce propolis extracts, assess their quality and effect on skin cells and determine the penetration of active ingredients from designed semi-solid topical formulations. The use of higher-concentration ethanol and a larger amount of raw material allows extracting a lar...
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| Format: | Article |
| Language: | English |
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Sciendo
2021-12-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0044 |
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| author | Ramanauskiene Kristina Inkeniene Asta Marija Perminaite Kristina Zilius Modestas Majiene Daiva |
| author_facet | Ramanauskiene Kristina Inkeniene Asta Marija Perminaite Kristina Zilius Modestas Majiene Daiva |
| author_sort | Ramanauskiene Kristina |
| collection | DOAJ |
| description | The aim of this study was to produce propolis extracts, assess their quality and effect on skin cells and determine the penetration of active ingredients from designed semi-solid topical formulations. The use of higher-concentration ethanol and a larger amount of raw material allows extracting a larger quantity of active ingredients from raw propolis. Ultrasound extraction is an effective method for the production of aqueous extracts of propolis. The results show that depending on concentration, propolis extracts reduce the viability of keratinocytes. The phenolic compounds under observation penetrated the epidermis and dermis from designed formulations. The base of semi-solid formulation influences the efficacy of propolis preparations. The overall quantity of phenolic compounds that penetrated the skin was around 2 % from the ointment and 1.5 % from the cream. |
| format | Article |
| id | doaj-art-671844d3a7da4c4486fece4191d80e11 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-671844d3a7da4c4486fece4191d80e112025-02-02T17:46:44ZengSciendoActa Pharmaceutica1846-95582021-12-0171465766710.2478/acph-2021-0044Propolis – quality analysis and use in topical formulationsRamanauskiene Kristina0Inkeniene Asta Marija1Perminaite Kristina2Zilius Modestas3Majiene Daiva4Department of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161Kaunas LithuaniaDepartment of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161Kaunas LithuaniaDepartment of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161Kaunas LithuaniaDepartment of Clinical Pharmacy, Lithuanian University of Health Sciences, Sukileliu Street 13, LT-50161Kaunas LithuaniaNeuroscience Institute, Lithuanian University of Health Sciences, Eivenių Street 4, Kaunas, LithuaniaThe aim of this study was to produce propolis extracts, assess their quality and effect on skin cells and determine the penetration of active ingredients from designed semi-solid topical formulations. The use of higher-concentration ethanol and a larger amount of raw material allows extracting a larger quantity of active ingredients from raw propolis. Ultrasound extraction is an effective method for the production of aqueous extracts of propolis. The results show that depending on concentration, propolis extracts reduce the viability of keratinocytes. The phenolic compounds under observation penetrated the epidermis and dermis from designed formulations. The base of semi-solid formulation influences the efficacy of propolis preparations. The overall quantity of phenolic compounds that penetrated the skin was around 2 % from the ointment and 1.5 % from the cream.https://doi.org/10.2478/acph-2021-0044phenolic compoundspropolis extractsskin penetrationcell viability |
| spellingShingle | Ramanauskiene Kristina Inkeniene Asta Marija Perminaite Kristina Zilius Modestas Majiene Daiva Propolis – quality analysis and use in topical formulations Acta Pharmaceutica phenolic compounds propolis extracts skin penetration cell viability |
| title | Propolis – quality analysis and use in topical formulations |
| title_full | Propolis – quality analysis and use in topical formulations |
| title_fullStr | Propolis – quality analysis and use in topical formulations |
| title_full_unstemmed | Propolis – quality analysis and use in topical formulations |
| title_short | Propolis – quality analysis and use in topical formulations |
| title_sort | propolis quality analysis and use in topical formulations |
| topic | phenolic compounds propolis extracts skin penetration cell viability |
| url | https://doi.org/10.2478/acph-2021-0044 |
| work_keys_str_mv | AT ramanauskienekristina propolisqualityanalysisanduseintopicalformulations AT inkenieneastamarija propolisqualityanalysisanduseintopicalformulations AT perminaitekristina propolisqualityanalysisanduseintopicalformulations AT ziliusmodestas propolisqualityanalysisanduseintopicalformulations AT majienedaiva propolisqualityanalysisanduseintopicalformulations |