Chromosomal integration and plasmid fusion occurring in ST20 carbapenem-resistant Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaIMP-4 induce resistance transmission and fitness variation

Chromosomal integration and plasmid fusion occurring in ST20 carbapenem-resistant Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaIMP-4 induce resistance transmission and fitness variation

To investigate the epidemiology of ST20 carbapenem-resistant Klebsiella pneumoniae (CRKP) in China, and further explore the genomic characteristics of blaIMP-4 and blaNDM-1 coharboring isolates and plasmid contributions to resistance and fitness. Seven ST20 CRKP isolates were collected nationwide, a...

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Main Authors: Qiucheng Shi, Huangdu Hu, Qian Yu, Weiyi Huang, Yinping Wang, Jingjing Quan, Junxin Zhou, Rui Weng, Ping Zhang, Yan Meng, Haiyang Liu, Yan Jiang, Yunsong Yu, Xiaoxing Du
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Carbapenem-resistant Klebsiella pneumoniae
ST20
NDM
chromosomal integrated IMP
plasmid recombination
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2339942
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