Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease
We evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years o...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/789506 |
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| author | Weidong Pan Shin Kwak Yun Liu Yan Sun Zhenglong Fang Baofeng Qin Yoshiharu Yamamoto |
| author_facet | Weidong Pan Shin Kwak Yun Liu Yan Sun Zhenglong Fang Baofeng Qin Yoshiharu Yamamoto |
| author_sort | Weidong Pan |
| collection | DOAJ |
| description | We evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years old) completed the study. Patients took either ZAZ2 (𝑛=59) or placebo granule (𝑛=56) in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants wore a motion logger, and we analyzed the power-law temporal autocorrelation of the motion logger records taken on 3 occasions (before, one week, and 13 weeks after the drug administration). Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS), as well as the power-law exponent α, which corresponds to the level of physical activity of the patients. ZAZ2 but not placebo granule improved the awake-sleep rhythm, the UPDRS Part II, Part II + III, and Part IV scores, and the α values. The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use. |
| format | Article |
| id | doaj-art-6700dedd8ff640ee8b456be7fda14d66 |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-6700dedd8ff640ee8b456be7fda14d662025-02-03T01:32:04ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/789506789506Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's DiseaseWeidong Pan0Shin Kwak1Yun Liu2Yan Sun3Zhenglong Fang4Baofeng Qin5Yoshiharu Yamamoto6Department of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Graduate School of Medicinel, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaDepartment of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, ChinaEducational Physiology Laboratory, Graduate School of Education, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, JapanWe evaluated the effects of a traditional Chinese medicine (TCM), named Zeng-xiao An-shen Zhi-chan 2 (ZAZ2), on patients with Parkinson's disease (PD). Among 115 patients with idiopathic PD enrolled (mean age, 64.7 ± 10.2 years old), 110 patients (M = 65, F = 45; mean age, 64.9 ± 10.7 years old) completed the study. Patients took either ZAZ2 (𝑛=59) or placebo granule (𝑛=56) in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants wore a motion logger, and we analyzed the power-law temporal autocorrelation of the motion logger records taken on 3 occasions (before, one week, and 13 weeks after the drug administration). Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS), as well as the power-law exponent α, which corresponds to the level of physical activity of the patients. ZAZ2 but not placebo granule improved the awake-sleep rhythm, the UPDRS Part II, Part II + III, and Part IV scores, and the α values. The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use.http://dx.doi.org/10.4061/2011/789506 |
| spellingShingle | Weidong Pan Shin Kwak Yun Liu Yan Sun Zhenglong Fang Baofeng Qin Yoshiharu Yamamoto Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease Parkinson's Disease |
| title | Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease |
| title_full | Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease |
| title_fullStr | Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease |
| title_full_unstemmed | Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease |
| title_short | Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease |
| title_sort | traditional chinese medicine improves activities of daily living in parkinson s disease |
| url | http://dx.doi.org/10.4061/2011/789506 |
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