Monocytes serve as Shiga toxin carriers during the development of hemolytic uremic syndrome

Monocytes serve as Shiga toxin carriers during the development of hemolytic uremic syndrome

Abstract Shiga toxin (Stx)-induced hemolytic uremic syndrome (HUS) poses a life-threatening complication for which a definitive treatment remains elusive. To exert its cytotoxic effect on renal cells, Stx must be delivered from the infected intestines to the kidney. However, the mechanism underlying...

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Bibliographic Details
Main Authors: Xinlei Sun, Shuang Qu, Fenglian Zhou, Fujie Shi, Yunfei Wu, Lin Gu, Minghui Liu, Zhen Bian, Lei Shi, Zhihong Liu, Yuan Liu, Ke Zen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Shiga toxin
Hemolytic uremic syndrome
Monocyte
Neutralizing antibody
Single-cell sequencing
Online Access:https://doi.org/10.1186/s11658-025-00689-8
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