T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections
The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tu...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/640309 |
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| author | Pascal Launois Annie Drowart Eliane Bourreau Pierre Couppie Claire-Michèle Farber Jean-Paul Van Vooren Kris Huygen |
| author_facet | Pascal Launois Annie Drowart Eliane Bourreau Pierre Couppie Claire-Michèle Farber Jean-Paul Van Vooren Kris Huygen |
| author_sort | Pascal Launois |
| collection | DOAJ |
| description | The mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen. |
| format | Article |
| id | doaj-art-66db2121e91c4d2b9649a0521cd714d8 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-66db2121e91c4d2b9649a0521cd714d82025-02-03T01:30:50ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/640309640309T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial InfectionsPascal Launois0Annie Drowart1Eliane Bourreau2Pierre Couppie3Claire-Michèle Farber4Jean-Paul Van Vooren5Kris Huygen6WHO-IRTC, Department of Biochemistry, University of Lausanne, Chemin des Boveresses, 1066 Epalinges, SwitzerlandHôpital Erasme, ULB, 1070 Bruxelles, BelgiumImmunologie des Leishmanioses, Institut Pasteur de la Guyane, 97306 Cayenne, French GuianaInstitut Guyanais de Dermatologie Tropicale, E.A. 2188, Centre hospitalier Andrée Rosemon, 97300 Cayenne, French GuianaHôpital Erasme, ULB, 1070 Bruxelles, BelgiumHôpital Erasme, ULB, 1070 Bruxelles, BelgiumScientific Service Immunology, O.D. Communicable and Infectious Diseases, WIV-ISP-IPH Site Ukkel, 642 Engelandstraat, 1180 Brussels, BelgiumThe mycolyl transferase antigen 85 complex is a major secreted protein family from mycobacterial culture filtrate, demonstrating powerful T cell stimulatory properties in most HIV-negative, tuberculin-positive volunteers with latent M.tuberculosis infection and only weak responses in HIV-negative tuberculosis patients. Here, we have analyzed T cell reactivity against PPD and Ag85 in HIV-infected individuals, without or with clinical symptoms of tuberculosis, and in AIDS patients with disease caused by nontuberculous mycobacteria. Whereas responses to PPD were not significantly different in HIV-negative and HIV-positive tuberculin-positive volunteers, responses to Ag85 were significantly decreased in the HIV-positive (CDC-A and CDC-B) group. Tuberculosis patients demonstrated low T cell reactivity against Ag85, irrespective of HIV infection, and finally AIDS patients suffering from NTM infections were completely nonreactive to Ag85. A one-year follow-up of twelve HIV-positive tuberculin-positive individuals indicated a decreased reactivity against Ag85 in patients developing clinical tuberculosis, highlighting the protective potential of this antigen.http://dx.doi.org/10.1155/2011/640309 |
| spellingShingle | Pascal Launois Annie Drowart Eliane Bourreau Pierre Couppie Claire-Michèle Farber Jean-Paul Van Vooren Kris Huygen T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections Clinical and Developmental Immunology |
| title | T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections |
| title_full | T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections |
| title_fullStr | T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections |
| title_full_unstemmed | T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections |
| title_short | T Cell Reactivity against Mycolyl Transferase Antigen 85 of M. tuberculosis in HIV-TB Coinfected Subjects and in AIDS Patients Suffering from Tuberculosis and Nontuberculous Mycobacterial Infections |
| title_sort | t cell reactivity against mycolyl transferase antigen 85 of m tuberculosis in hiv tb coinfected subjects and in aids patients suffering from tuberculosis and nontuberculous mycobacterial infections |
| url | http://dx.doi.org/10.1155/2011/640309 |
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