Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention
Dihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese Traditional Medicine. It has attracted considerable attention from consumers due to its beneficial properties including anticancer, antioxidative, and...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/6692579 |
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| _version_ | 1832563219788464128 |
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| author | Liang Chen Meng Shi Chenghao Lv Ying Song Yuanjie Wu Suifei Liu Zhibing Zheng Xiangyang Lu Si Qin |
| author_facet | Liang Chen Meng Shi Chenghao Lv Ying Song Yuanjie Wu Suifei Liu Zhibing Zheng Xiangyang Lu Si Qin |
| author_sort | Liang Chen |
| collection | DOAJ |
| description | Dihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese Traditional Medicine. It has attracted considerable attention from consumers due to its beneficial properties including anticancer, antioxidative, and anti-inflammatory activities. Continuous oxidative stress caused by intracellular redox imbalance can lead to chronic inflammation, which is intimately associated with the initiation, promotion, and progression of cancer. DHM is considered a potential redox regulator for chronic disease prevention, and its biological activities are abundantly evaluated by using diverse cell and animal models. However, clinical investigations are still scanty. This review summarizes the current potential chemopreventive effects of DHM, including its properties such as anticancer, antioxidative, and anti-inflammatory activities, and further discusses the underlying molecular mechanisms of DHM in cancer chemoprevention by targeting redox balance and influencing the gut microbiota. |
| format | Article |
| id | doaj-art-66d7bfd7719f4482b9551ad0fb45119c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-66d7bfd7719f4482b9551ad0fb45119c2025-02-03T01:20:44ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/66925796692579Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer ChemopreventionLiang Chen0Meng Shi1Chenghao Lv2Ying Song3Yuanjie Wu4Suifei Liu5Zhibing Zheng6Xiangyang Lu7Si Qin8College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, ChinaHunan Tea Group Co., Ltd., Changsha 410128, ChinaJiangxi Agricultural Engineering College, Yichun 331200, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, ChinaDihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese Traditional Medicine. It has attracted considerable attention from consumers due to its beneficial properties including anticancer, antioxidative, and anti-inflammatory activities. Continuous oxidative stress caused by intracellular redox imbalance can lead to chronic inflammation, which is intimately associated with the initiation, promotion, and progression of cancer. DHM is considered a potential redox regulator for chronic disease prevention, and its biological activities are abundantly evaluated by using diverse cell and animal models. However, clinical investigations are still scanty. This review summarizes the current potential chemopreventive effects of DHM, including its properties such as anticancer, antioxidative, and anti-inflammatory activities, and further discusses the underlying molecular mechanisms of DHM in cancer chemoprevention by targeting redox balance and influencing the gut microbiota.http://dx.doi.org/10.1155/2021/6692579 |
| spellingShingle | Liang Chen Meng Shi Chenghao Lv Ying Song Yuanjie Wu Suifei Liu Zhibing Zheng Xiangyang Lu Si Qin Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention Mediators of Inflammation |
| title | Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention |
| title_full | Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention |
| title_fullStr | Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention |
| title_full_unstemmed | Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention |
| title_short | Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention |
| title_sort | dihydromyricetin acts as a potential redox balance mediator in cancer chemoprevention |
| url | http://dx.doi.org/10.1155/2021/6692579 |
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