Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury
Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/9260592 |
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| _version_ | 1832559213653524480 |
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| author | Alistair E. Cole Simon S. Murray Junhua Xiao |
| author_facet | Alistair E. Cole Simon S. Murray Junhua Xiao |
| author_sort | Alistair E. Cole |
| collection | DOAJ |
| description | Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precursor cells in the embryonic, postnatal, and injured CNS. Here we review recent studies on BMP4 signalling in the generation of neurons, astrocytes, and oligodendroglial cells in the CNS. We also discuss putative mechanisms that BMP4 may utilise to influence glial cell development following CNS injury and highlight some questions for further research. |
| format | Article |
| id | doaj-art-66af4cae5d8d43ffbafb9a84d82f5a21 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-66af4cae5d8d43ffbafb9a84d82f5a212025-02-03T01:30:35ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/92605929260592Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after InjuryAlistair E. Cole0Simon S. Murray1Junhua Xiao2Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Parkville, VIC 3010, AustraliaDepartment of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Parkville, VIC 3010, AustraliaSubstantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precursor cells in the embryonic, postnatal, and injured CNS. Here we review recent studies on BMP4 signalling in the generation of neurons, astrocytes, and oligodendroglial cells in the CNS. We also discuss putative mechanisms that BMP4 may utilise to influence glial cell development following CNS injury and highlight some questions for further research.http://dx.doi.org/10.1155/2016/9260592 |
| spellingShingle | Alistair E. Cole Simon S. Murray Junhua Xiao Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury Stem Cells International |
| title | Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury |
| title_full | Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury |
| title_fullStr | Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury |
| title_full_unstemmed | Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury |
| title_short | Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury |
| title_sort | bone morphogenetic protein 4 signalling in neural stem and progenitor cells during development and after injury |
| url | http://dx.doi.org/10.1155/2016/9260592 |
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