Effect of decreasing respiratory rate on the mechanical power of ventilation and lung injury biomarkers: a randomized cross-over clinical study in COVID-19 ARDS patients

Effect of decreasing respiratory rate on the mechanical power of ventilation and lung injury biomarkers: a randomized cross-over clinical study in COVID-19 ARDS patients

Abstract Background The respiratory rate (RR) is a key determinant of the mechanical power of ventilation (MP). The effect of reducing the RR on MP and its potential to mitigate ventilator-induced lung injury remains unclear. Objectives To compare invasive ventilation using a lower versus a higher R...

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Main Authors: L. Felipe Damiani, Roque Basoalto, Vanessa Oviedo, Leyla Alegria, Dagoberto Soto, M. Consuelo Bachmann, Yorschua Jalil, Cesar Santis, David Carpio, Rodrigo Ulloa, Daniel Valenzuela, Magdalena Vera, Marcus J. Schultz, Jaime Retamal, Alejandro Bruhn, Guillermo Bugedo
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Intensive Care Medicine Experimental
Subjects:
ARDS
Invasive ventilation
Respiratory rate
Mechanical power of ventilation
MP
Ventilator-induced lung injury
Online Access:https://doi.org/10.1186/s40635-025-00782-4
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