Salivary gland stem/progenitor cells: advancing from basic science to clinical applications
Abstract Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren’s syndrome, and aging. This review provides a comprehensive overview...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Cell Regeneration |
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| Online Access: | https://doi.org/10.1186/s13619-025-00221-5 |
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| _version_ | 1832585641145139200 |
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| author | Jimpi Langthasa Li Guan Shyam Lal Jinagal Quynh-Thu Le |
| author_facet | Jimpi Langthasa Li Guan Shyam Lal Jinagal Quynh-Thu Le |
| author_sort | Jimpi Langthasa |
| collection | DOAJ |
| description | Abstract Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren’s syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, and their role in tissue regeneration. Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions. |
| format | Article |
| id | doaj-art-66a628c7614a4c1fb1f74979ce08e0f2 |
| institution | Kabale University |
| issn | 2045-9769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj-art-66a628c7614a4c1fb1f74979ce08e0f22025-01-26T12:36:38ZengSpringerOpenCell Regeneration2045-97692025-01-011411810.1186/s13619-025-00221-5Salivary gland stem/progenitor cells: advancing from basic science to clinical applicationsJimpi Langthasa0Li Guan1Shyam Lal Jinagal2Quynh-Thu Le3Department of Radiation Oncology, Stanford University School of MedicineDepartment of Radiation Oncology, Stanford University School of MedicineGladstone InstitutesDepartment of Radiation Oncology, Stanford University School of MedicineAbstract Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially for patients suffering from salivary gland dysfunction due to various causes such as radiation therapy, Sjögren’s syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, and their role in tissue regeneration. Additionally, we highlight recent advances in cell- and tissue-based therapies, such as SSPC transplantation and bioengineered organ replacements. The challenges in translating SSPC research into effective clinical therapies are also discussed, alongside proposed solutions and future research directions.https://doi.org/10.1186/s13619-025-00221-5Salivary glandsSalivary gland stem/progenitor cells (SSPCs)Clinical implicationsRegenerative medicine |
| spellingShingle | Jimpi Langthasa Li Guan Shyam Lal Jinagal Quynh-Thu Le Salivary gland stem/progenitor cells: advancing from basic science to clinical applications Cell Regeneration Salivary glands Salivary gland stem/progenitor cells (SSPCs) Clinical implications Regenerative medicine |
| title | Salivary gland stem/progenitor cells: advancing from basic science to clinical applications |
| title_full | Salivary gland stem/progenitor cells: advancing from basic science to clinical applications |
| title_fullStr | Salivary gland stem/progenitor cells: advancing from basic science to clinical applications |
| title_full_unstemmed | Salivary gland stem/progenitor cells: advancing from basic science to clinical applications |
| title_short | Salivary gland stem/progenitor cells: advancing from basic science to clinical applications |
| title_sort | salivary gland stem progenitor cells advancing from basic science to clinical applications |
| topic | Salivary glands Salivary gland stem/progenitor cells (SSPCs) Clinical implications Regenerative medicine |
| url | https://doi.org/10.1186/s13619-025-00221-5 |
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