Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease
Background. Six-minute walk test (6MWT) has 3 measurement outcomes, which are walk distance, desaturation, and symptom. The aim of this study was to examine whether routinely measured right-heart catheter (RHC) data correlate with 6MWT outcomes in patients with interstitial lung disease (ILD). Metho...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/3837182 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559280414261248 |
|---|---|
| author | Osamu Nishiyama Ryo Yamazaki Hiroyuki Sano Takashi Iwanaga Yuji Higashimoto Hiroaki Kume Yuji Tohda |
| author_facet | Osamu Nishiyama Ryo Yamazaki Hiroyuki Sano Takashi Iwanaga Yuji Higashimoto Hiroaki Kume Yuji Tohda |
| author_sort | Osamu Nishiyama |
| collection | DOAJ |
| description | Background. Six-minute walk test (6MWT) has 3 measurement outcomes, which are walk distance, desaturation, and symptom. The aim of this study was to examine whether routinely measured right-heart catheter (RHC) data correlate with 6MWT outcomes in patients with interstitial lung disease (ILD). Methods. Between June 2010 and December 2012, consecutive patients with ILD who underwent evaluation, including pulmonary function test, hemodynamic studies with right-heart catheter, and 6MWT as routine general practice, were recruited. Correlates of 3 outcomes of 6MWT were examined to reveal significant predictors. Results. Forty-six patients consisting of 20 with idiopathic pulmonary fibrosis, 14 with collagen vascular disease associated ILD, and 12 with other idiopathic interstitial pneumonia were recruited (mean % predicted FVC: 76.7±17.1%). Several physiological variables, including mean pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), were correlated with each 6MWT outcome. Stepwise multivariate regression analyses showed that % predicted FVC and % predicted DLco were independent predictors of walk distance (r2=0.35, p=0.0002). For SpO2 at the end of 6MWT, % predicted DLco and PVR were selected as independent predictors (r2=0.46, p<0.0001). For dyspnea at the end of 6MWT, % predicted DLco was only one predictor (r2=0.18, p=0.005). Conclusion. Mean PAP had little impact on 6MWT outcomes in ILD patients who were nonselectively recruited, although PVR was one of predictors of desaturation. |
| format | Article |
| id | doaj-art-669cf9d7bb7944449b9b80d9a5a68064 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-669cf9d7bb7944449b9b80d9a5a680642025-02-03T01:30:29ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/38371823837182Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung DiseaseOsamu Nishiyama0Ryo Yamazaki1Hiroyuki Sano2Takashi Iwanaga3Yuji Higashimoto4Hiroaki Kume5Yuji Tohda6Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, Osaka 589-8511, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, Osaka 589-8511, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, Osaka 589-8511, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, Osaka 589-8511, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, Osaka 589-8511, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, Osaka 589-8511, JapanDepartment of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Onohigashi, Osakasayama, Osaka 589-8511, JapanBackground. Six-minute walk test (6MWT) has 3 measurement outcomes, which are walk distance, desaturation, and symptom. The aim of this study was to examine whether routinely measured right-heart catheter (RHC) data correlate with 6MWT outcomes in patients with interstitial lung disease (ILD). Methods. Between June 2010 and December 2012, consecutive patients with ILD who underwent evaluation, including pulmonary function test, hemodynamic studies with right-heart catheter, and 6MWT as routine general practice, were recruited. Correlates of 3 outcomes of 6MWT were examined to reveal significant predictors. Results. Forty-six patients consisting of 20 with idiopathic pulmonary fibrosis, 14 with collagen vascular disease associated ILD, and 12 with other idiopathic interstitial pneumonia were recruited (mean % predicted FVC: 76.7±17.1%). Several physiological variables, including mean pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), were correlated with each 6MWT outcome. Stepwise multivariate regression analyses showed that % predicted FVC and % predicted DLco were independent predictors of walk distance (r2=0.35, p=0.0002). For SpO2 at the end of 6MWT, % predicted DLco and PVR were selected as independent predictors (r2=0.46, p<0.0001). For dyspnea at the end of 6MWT, % predicted DLco was only one predictor (r2=0.18, p=0.005). Conclusion. Mean PAP had little impact on 6MWT outcomes in ILD patients who were nonselectively recruited, although PVR was one of predictors of desaturation.http://dx.doi.org/10.1155/2016/3837182 |
| spellingShingle | Osamu Nishiyama Ryo Yamazaki Hiroyuki Sano Takashi Iwanaga Yuji Higashimoto Hiroaki Kume Yuji Tohda Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease Canadian Respiratory Journal |
| title | Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease |
| title_full | Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease |
| title_fullStr | Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease |
| title_full_unstemmed | Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease |
| title_short | Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease |
| title_sort | pulmonary hemodynamics and six minute walk test outcomes in patients with interstitial lung disease |
| url | http://dx.doi.org/10.1155/2016/3837182 |
| work_keys_str_mv | AT osamunishiyama pulmonaryhemodynamicsandsixminutewalktestoutcomesinpatientswithinterstitiallungdisease AT ryoyamazaki pulmonaryhemodynamicsandsixminutewalktestoutcomesinpatientswithinterstitiallungdisease AT hiroyukisano pulmonaryhemodynamicsandsixminutewalktestoutcomesinpatientswithinterstitiallungdisease AT takashiiwanaga pulmonaryhemodynamicsandsixminutewalktestoutcomesinpatientswithinterstitiallungdisease AT yujihigashimoto pulmonaryhemodynamicsandsixminutewalktestoutcomesinpatientswithinterstitiallungdisease AT hiroakikume pulmonaryhemodynamicsandsixminutewalktestoutcomesinpatientswithinterstitiallungdisease AT yujitohda pulmonaryhemodynamicsandsixminutewalktestoutcomesinpatientswithinterstitiallungdisease |