Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life
Background and aims. Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two ye...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/425759 |
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| author | P. B. Jeppesen P. Lund I. B. Gottschalck H. B. Nielsen J. J. Holst J. Mortensen S. S. Poulsen B. Quistorff P. B. Mortensen |
| author_facet | P. B. Jeppesen P. Lund I. B. Gottschalck H. B. Nielsen J. J. Holst J. Mortensen S. S. Poulsen B. Quistorff P. B. Mortensen |
| author_sort | P. B. Jeppesen |
| collection | DOAJ |
| description | Background and aims. Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two years of subcutaneous GLP-2 treatment, 400 microgram TID, intermitted by an 8-week washout period.
Methods. Safety and compliance was evaluated during the admissions. The Sickness Impact Profile (SIP), Short Form 36 (SF 36), and Inflammatory Bowel Disease Questionnaire (IBDQ) evaluated quality of life.
Results. The predominant adverse event was transient abdominal discomfort in 5 of 11 patients, but in 2, both suffering from Crohns disease, it progressed to abdominal pain and led to discontinuation of GLP-2 treatment. One had a fibrostenotic lesion electively resected at the jejuno-ascendo-anastomosis. The investigator excluded a patient due to unreliable feedback. Stoma nipple enlargement was seen in all 9 jejunostomy patients. Reported GLP-2 compliance was excellent (>93%). GLP-2 improved the overall quality of life VAS-score (4.1±2.8 cm versus 6.0±2.4 cm, 𝑃<.01), the overall SIP score (10.3±8.9% versus 6.2±9.5%, 𝑃<.001), the mental component of the SF-36 (45±13% versus 53±11%, 𝑃<.05), and the overall IBDQ score (5.1±0.9 versus 5.4±0.9, 𝑃<.007) in the 8 patients completing the study.
Conclusions. Long-term treatment with GLP-2 is feasible in SBS patients, although caution must be exercised in patients with a history of abdominal pain. Although conclusions cannot be made in a noncontrolled trial, the high reported compliance might reflect a high treatment satisfaction, where the clinical benefits of GLP-2 may outweigh the discomforts of injections. |
| format | Article |
| id | doaj-art-669af1ecb1d44596b8f053b863017be7 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-669af1ecb1d44596b8f053b863017be72025-02-03T01:10:30ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/425759425759Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of LifeP. B. Jeppesen0P. Lund1I. B. Gottschalck2H. B. Nielsen3J. J. Holst4J. Mortensen5S. S. Poulsen6B. Quistorff7P. B. Mortensen8Department of Gastroenterology, Copenhagen University Hospital (Rigshospitalet), 2121 Copenhagen, DenmarkDepartment of Gastroenterology, Copenhagen University Hospital (Rigshospitalet), 2121 Copenhagen, DenmarkDepartment of Gastroenterology, Copenhagen University Hospital (Rigshospitalet), 2121 Copenhagen, DenmarkDepartment of Anesthesia, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, DenmarkDepartment of Biomedical Sciences, The Panum Institute, 2200 Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital (Rigshospitalet), 2100 Copenhagen, DenmarkDepartment of Biomedical Sciences, The Panum Institute, 2200 Copenhagen, DenmarkDepartment of Biomedical Sciences, The Panum Institute, 2200 Copenhagen, DenmarkDepartment of Gastroenterology, Copenhagen University Hospital (Rigshospitalet), 2121 Copenhagen, DenmarkBackground and aims. Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients in a short-term study. This study describes safety, compliance, and changes in quality of life in 11 SBS patients at baseline, week 13, 26, and 52 during two years of subcutaneous GLP-2 treatment, 400 microgram TID, intermitted by an 8-week washout period. Methods. Safety and compliance was evaluated during the admissions. The Sickness Impact Profile (SIP), Short Form 36 (SF 36), and Inflammatory Bowel Disease Questionnaire (IBDQ) evaluated quality of life. Results. The predominant adverse event was transient abdominal discomfort in 5 of 11 patients, but in 2, both suffering from Crohns disease, it progressed to abdominal pain and led to discontinuation of GLP-2 treatment. One had a fibrostenotic lesion electively resected at the jejuno-ascendo-anastomosis. The investigator excluded a patient due to unreliable feedback. Stoma nipple enlargement was seen in all 9 jejunostomy patients. Reported GLP-2 compliance was excellent (>93%). GLP-2 improved the overall quality of life VAS-score (4.1±2.8 cm versus 6.0±2.4 cm, 𝑃<.01), the overall SIP score (10.3±8.9% versus 6.2±9.5%, 𝑃<.001), the mental component of the SF-36 (45±13% versus 53±11%, 𝑃<.05), and the overall IBDQ score (5.1±0.9 versus 5.4±0.9, 𝑃<.007) in the 8 patients completing the study. Conclusions. Long-term treatment with GLP-2 is feasible in SBS patients, although caution must be exercised in patients with a history of abdominal pain. Although conclusions cannot be made in a noncontrolled trial, the high reported compliance might reflect a high treatment satisfaction, where the clinical benefits of GLP-2 may outweigh the discomforts of injections.http://dx.doi.org/10.1155/2009/425759 |
| spellingShingle | P. B. Jeppesen P. Lund I. B. Gottschalck H. B. Nielsen J. J. Holst J. Mortensen S. S. Poulsen B. Quistorff P. B. Mortensen Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life Gastroenterology Research and Practice |
| title | Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life |
| title_full | Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life |
| title_fullStr | Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life |
| title_full_unstemmed | Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life |
| title_short | Short Bowel Patients Treated for Two Years with Glucagon-Like Peptide 2 (GLP-2): Compliance, Safety, and Effects on Quality of Life |
| title_sort | short bowel patients treated for two years with glucagon like peptide 2 glp 2 compliance safety and effects on quality of life |
| url | http://dx.doi.org/10.1155/2009/425759 |
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