HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China
Purpose. Human papillomavirus (HPV) as a risk factor for esophageal squamous cell carcinoma (ESCC) has previously been studied, but importance of HPV status in ESCC for prognosis is less clear. Methods. A total of 105 specimens with ESCC were tested by in situ hybridization for HPV 16/18 and immunoh...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/804738 |
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| author | Fangli Cao Hui Han Fang Zhang Baozhong Wang Wei Ma Yanwen Wang Guiming Sun Miao Shi Yubo Ren Yufeng Cheng |
| author_facet | Fangli Cao Hui Han Fang Zhang Baozhong Wang Wei Ma Yanwen Wang Guiming Sun Miao Shi Yubo Ren Yufeng Cheng |
| author_sort | Fangli Cao |
| collection | DOAJ |
| description | Purpose. Human papillomavirus (HPV) as a risk factor for esophageal squamous cell carcinoma (ESCC) has previously been studied, but importance of HPV status in ESCC for prognosis is less clear. Methods. A total of 105 specimens with ESCC were tested by in situ hybridization for HPV 16/18 and immunohistochemistry for p16 expression. The 5-year overall survival (OS) and progression-free survival were calculated in relation to these markers and the Cox proportional hazards model was used to determine the hazard ratio (HR) of variables in univariate and multivariate analysis. Results. HPV was detected in 27.6% (29) of the 105 patients with ESCC, and all positive cases were HPV-16. Twenty-five (86.2%) of the 29 HPV-positive tumors were stained positive for p16. HPV infected patients had better 5-year rates of OS (65.9% versus 43.4% among patients with HPV-negative tumors; P = 0.002 by the log-rank test) and had a 63% reduction in the risk of death (adjusted HR = 0.37, 95% CI = 0.16 to 0.82, and P = 0.01). Conclusions. HPV infection may be one of many factors contributing to the development of ESCC and tumor HPV status is an independent prognostic factor for survival among patients with ESCC. |
| format | Article |
| id | doaj-art-669739c45d544827ab9813d53709d161 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-669739c45d544827ab9813d53709d1612025-02-03T01:24:03ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/804738804738HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern ChinaFangli Cao0Hui Han1Fang Zhang2Baozhong Wang3Wei Ma4Yanwen Wang5Guiming Sun6Miao Shi7Yubo Ren8Yufeng Cheng9Department of Radiation Oncology, Qilu Hospital of Shandong University, No. 44 Wenhua Xi Road, Jinan 250012, ChinaDepartment of Oncology, Liaocheng People’s Hospital, Liaocheng 252000, ChinaDepartment of Oncology, The First Hospital of Zibo, Zibo 255000, ChinaDepartment of Oncology, Liaocheng People’s Hospital, Liaocheng 252000, ChinaDepartment of Radiation Oncology, Cancer Hospital, General Hospital of Ningxia Medical University, Yinchuan 750000, ChinaDepartment of Oncology, Liaocheng People’s Hospital, Liaocheng 252000, ChinaDepartment of Oncology, Liaocheng People’s Hospital, Liaocheng 252000, ChinaDepartment of Ultrasound, Liaocheng People’s Hospital, Liaocheng 252000, ChinaDepartment of Pathology, Liaocheng People’s Hospital, Liaocheng 252000, ChinaDepartment of Radiation Oncology, Qilu Hospital of Shandong University, No. 44 Wenhua Xi Road, Jinan 250012, ChinaPurpose. Human papillomavirus (HPV) as a risk factor for esophageal squamous cell carcinoma (ESCC) has previously been studied, but importance of HPV status in ESCC for prognosis is less clear. Methods. A total of 105 specimens with ESCC were tested by in situ hybridization for HPV 16/18 and immunohistochemistry for p16 expression. The 5-year overall survival (OS) and progression-free survival were calculated in relation to these markers and the Cox proportional hazards model was used to determine the hazard ratio (HR) of variables in univariate and multivariate analysis. Results. HPV was detected in 27.6% (29) of the 105 patients with ESCC, and all positive cases were HPV-16. Twenty-five (86.2%) of the 29 HPV-positive tumors were stained positive for p16. HPV infected patients had better 5-year rates of OS (65.9% versus 43.4% among patients with HPV-negative tumors; P = 0.002 by the log-rank test) and had a 63% reduction in the risk of death (adjusted HR = 0.37, 95% CI = 0.16 to 0.82, and P = 0.01). Conclusions. HPV infection may be one of many factors contributing to the development of ESCC and tumor HPV status is an independent prognostic factor for survival among patients with ESCC.http://dx.doi.org/10.1155/2014/804738 |
| spellingShingle | Fangli Cao Hui Han Fang Zhang Baozhong Wang Wei Ma Yanwen Wang Guiming Sun Miao Shi Yubo Ren Yufeng Cheng HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China The Scientific World Journal |
| title | HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China |
| title_full | HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China |
| title_fullStr | HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China |
| title_full_unstemmed | HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China |
| title_short | HPV Infection in Esophageal Squamous Cell Carcinoma and Its Relationship to the Prognosis of Patients in Northern China |
| title_sort | hpv infection in esophageal squamous cell carcinoma and its relationship to the prognosis of patients in northern china |
| url | http://dx.doi.org/10.1155/2014/804738 |
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