Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis
Purpose. To investigate the retinal nerve fibre layer (RNFL) thickness after unilateral acute optic neuritis using optical coherence tomography (OCT). Patients and Methods. This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis....
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/694613 |
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| author | Gordon S. K. Yau Jacky W. Y. Lee Patrick P. K. Lau Victor T. Y. Tam Winnie W. Y. Wong Can Y. F. Yuen |
| author_facet | Gordon S. K. Yau Jacky W. Y. Lee Patrick P. K. Lau Victor T. Y. Tam Winnie W. Y. Wong Can Y. F. Yuen |
| author_sort | Gordon S. K. Yau |
| collection | DOAJ |
| description | Purpose. To investigate the retinal nerve fibre layer (RNFL) thickness after unilateral acute optic neuritis using optical coherence tomography (OCT). Patients and Methods. This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis. RNFL thickness and visual acuity (VA) of the attack and normal fellow eye were measured at presentation and 3 months in both the treatment and nontreatment groups. Results. 11 subjects received systemic steroids and 9 were treated conservatively. The baseline RNFL thickness was similar in the attack and fellow eye (P≥0.4). At 3 months, the attack eye had a thinner temporal (P=0.02) and average (P=0.05) RNFL compared to the fellow eye. At 3 months, the attack eye had significant RNFL thinning in the 4 quadrants and average thickness (P≤0.0002) compared to baseline. The RNFL thickness between the treatment and nontreatment groups was similar at baseline and 3 months (P≥0.1). Treatment offered better VA at 3 months (0.1 ± 0.2 versus 0.3 ± 0.2 LogMAR, P=0.04). Conclusion. Generalized RNFL thinning occurred at 3 months after a first episode of acute optic neuritis most significantly in the temporal quadrant and average thickness. Visual improvement with treatment was independent of RNFL thickness. |
| format | Article |
| id | doaj-art-669513147ef247dd8e8b538e79bc3991 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-669513147ef247dd8e8b538e79bc39912025-02-03T05:48:22ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/694613694613Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic NeuritisGordon S. K. Yau0Jacky W. Y. Lee1Patrick P. K. Lau2Victor T. Y. Tam3Winnie W. Y. Wong4Can Y. F. Yuen5Department of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong KongDepartment of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong KongDepartment of Medicine and Geriatric, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong KongDepartment of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong KongDepartment of Medicine and Geriatric, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong KongDepartment of Ophthalmology, Caritas Medical Centre, 111 Wing Hong Street, Kowloon, Hong KongPurpose. To investigate the retinal nerve fibre layer (RNFL) thickness after unilateral acute optic neuritis using optical coherence tomography (OCT). Patients and Methods. This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis. RNFL thickness and visual acuity (VA) of the attack and normal fellow eye were measured at presentation and 3 months in both the treatment and nontreatment groups. Results. 11 subjects received systemic steroids and 9 were treated conservatively. The baseline RNFL thickness was similar in the attack and fellow eye (P≥0.4). At 3 months, the attack eye had a thinner temporal (P=0.02) and average (P=0.05) RNFL compared to the fellow eye. At 3 months, the attack eye had significant RNFL thinning in the 4 quadrants and average thickness (P≤0.0002) compared to baseline. The RNFL thickness between the treatment and nontreatment groups was similar at baseline and 3 months (P≥0.1). Treatment offered better VA at 3 months (0.1 ± 0.2 versus 0.3 ± 0.2 LogMAR, P=0.04). Conclusion. Generalized RNFL thinning occurred at 3 months after a first episode of acute optic neuritis most significantly in the temporal quadrant and average thickness. Visual improvement with treatment was independent of RNFL thickness.http://dx.doi.org/10.1155/2013/694613 |
| spellingShingle | Gordon S. K. Yau Jacky W. Y. Lee Patrick P. K. Lau Victor T. Y. Tam Winnie W. Y. Wong Can Y. F. Yuen Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis The Scientific World Journal |
| title | Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis |
| title_full | Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis |
| title_fullStr | Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis |
| title_full_unstemmed | Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis |
| title_short | Prospective Study on Retinal Nerve Fibre Layer Thickness Changes in Isolated Unilateral Retrobulbar Optic Neuritis |
| title_sort | prospective study on retinal nerve fibre layer thickness changes in isolated unilateral retrobulbar optic neuritis |
| url | http://dx.doi.org/10.1155/2013/694613 |
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