In silico screening of naturally derived dietary compounds as potential butyrylcholinesterase inhibitors for Alzheimer’s disease treatment

In silico screening of naturally derived dietary compounds as potential butyrylcholinesterase inhibitors for Alzheimer’s disease treatment

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative condition that causes a substantial decline in cognitive functions and affects memory, thinking abilities, and daily behavior. The most prominent hallmark of AD pathogenesis is the formation of amyloid-β plaques, among other associ...

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Main Authors: Md. Tarikul Islam, Md. Aktaruzzaman, Chandan Barai, Farhan Ishrak Rafi, Al Riyad Hasan, Tasfiah Tasnim, Parvej Sarder, Ghadeer M. Albadrani, Muath Q. Al-Ghadi, Amany A. Sayed, Mohamed M. Abdel-Daim, Humayra Afroz Dona, Kishore Kumar Sarkar, Md. Obayed Raihan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
Butyrylcholinesterase
Molecular docking
MM-GBSA
Pharmacokinetics
Molecular dynamics simulations
Online Access:https://doi.org/10.1038/s41598-025-98092-y
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