Diffuse Neurofibroma in a Patient with Unknown History of NF1
Malignant peripheral nerve sheath tumor (MPNST) is a rare disease in the parotid gland with a poor prognosis in most cases. The disease most often develops in the setting of neurofibromatosis type 1 (NF1) but can also occur sporadically. Herein, we report a rare case of MPNST in the parotid gland, i...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2018/8768472 |
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| author | Mahmoud A. K. Ebrahim Mishal M. AlMutairi Khaled M. Hindi Jassem M. Bastaki |
| author_facet | Mahmoud A. K. Ebrahim Mishal M. AlMutairi Khaled M. Hindi Jassem M. Bastaki |
| author_sort | Mahmoud A. K. Ebrahim |
| collection | DOAJ |
| description | Malignant peripheral nerve sheath tumor (MPNST) is a rare disease in the parotid gland with a poor prognosis in most cases. The disease most often develops in the setting of neurofibromatosis type 1 (NF1) but can also occur sporadically. Herein, we report a rare case of MPNST in the parotid gland, in a patient with no previous history of NF1. Initial investigations of the patient, which consisted of laboratory investigations, ultrasound imaging of the swelling, fine-needle aspiration (FNA), computed tomography (CT) scan, and magnetic resonance imaging (MRI) of the neck and swelling, were compatible with a benign pleomorphic adenoma of the parotid gland. However, intraoperatively, the dissection was challenging as the tumor was adherent to the neighboring tissue. A diagnosis of MPNST arising from a diffuse neurofibroma was established based on clinicopathologic features of the disease. The patient, who exhibited clinical features compatible with (NF1), proceeded for radiotherapy following surgery to continue his treatment. |
| format | Article |
| id | doaj-art-668836368a384934a0aa69477370386d |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-668836368a384934a0aa69477370386d2025-02-03T05:52:03ZengWileyCase Reports in Otolaryngology2090-67652090-67732018-01-01201810.1155/2018/87684728768472Diffuse Neurofibroma in a Patient with Unknown History of NF1Mahmoud A. K. Ebrahim0Mishal M. AlMutairi1Khaled M. Hindi2Jassem M. Bastaki3Farwaniya Hospital, Ministry of Health, Kuwait City, KuwaitZain Hospital, Ministry of Health, Kuwait City, KuwaitKuwait Institute Medical Specialties, Kuwait City, KuwaitAl-Sabah Hospital, Ministry of Health, Kuwait City, KuwaitMalignant peripheral nerve sheath tumor (MPNST) is a rare disease in the parotid gland with a poor prognosis in most cases. The disease most often develops in the setting of neurofibromatosis type 1 (NF1) but can also occur sporadically. Herein, we report a rare case of MPNST in the parotid gland, in a patient with no previous history of NF1. Initial investigations of the patient, which consisted of laboratory investigations, ultrasound imaging of the swelling, fine-needle aspiration (FNA), computed tomography (CT) scan, and magnetic resonance imaging (MRI) of the neck and swelling, were compatible with a benign pleomorphic adenoma of the parotid gland. However, intraoperatively, the dissection was challenging as the tumor was adherent to the neighboring tissue. A diagnosis of MPNST arising from a diffuse neurofibroma was established based on clinicopathologic features of the disease. The patient, who exhibited clinical features compatible with (NF1), proceeded for radiotherapy following surgery to continue his treatment.http://dx.doi.org/10.1155/2018/8768472 |
| spellingShingle | Mahmoud A. K. Ebrahim Mishal M. AlMutairi Khaled M. Hindi Jassem M. Bastaki Diffuse Neurofibroma in a Patient with Unknown History of NF1 Case Reports in Otolaryngology |
| title | Diffuse Neurofibroma in a Patient with Unknown History of NF1 |
| title_full | Diffuse Neurofibroma in a Patient with Unknown History of NF1 |
| title_fullStr | Diffuse Neurofibroma in a Patient with Unknown History of NF1 |
| title_full_unstemmed | Diffuse Neurofibroma in a Patient with Unknown History of NF1 |
| title_short | Diffuse Neurofibroma in a Patient with Unknown History of NF1 |
| title_sort | diffuse neurofibroma in a patient with unknown history of nf1 |
| url | http://dx.doi.org/10.1155/2018/8768472 |
| work_keys_str_mv | AT mahmoudakebrahim diffuseneurofibromainapatientwithunknownhistoryofnf1 AT mishalmalmutairi diffuseneurofibromainapatientwithunknownhistoryofnf1 AT khaledmhindi diffuseneurofibromainapatientwithunknownhistoryofnf1 AT jassemmbastaki diffuseneurofibromainapatientwithunknownhistoryofnf1 |