Melatonin ameliorates zearalenone-induced ovarian damage in mice through antioxidative effects

Melatonin ameliorates zearalenone-induced ovarian damage in mice through antioxidative effects

IntroductionZearalenone (ZEN), a mycotoxin from Fusarium species, is widely present in contaminated grains and animal products. It exerts estrogen-like effects, disrupting hormonal balance and reproductive function, partly through oxidative stress-induced DNA damage. The ATM-Chk2-p53 pathway is a ke...

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Bibliographic Details
Main Authors: Yi Song, Zhong Guo, Lei Song, Jianxiu Ma, Zhifang Zhao, Yanqing Ma, Xiaoyue Ma, Wenjie Jiang, Wanjing Wang, Chongran Liu, Tongtong Wei, Ling Fu, Zhengli Qi, Jin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Veterinary Science
Subjects:
melatonin
zearalenone
ovarian
ATM-Chk2-P53 signaling pathway
γH2AX
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1587391/full
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