Therapeutic potential of SOX family transcription factors in osteoarthritis
Background As the worldwide population ages, osteoarthritis has significantly increased. This musculoskeletal condition has become a pressing global health issue and thus, prevention and treatment of osteoarthritis have become the primary focus of domestic and international research. Scholarly inves...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2457520 |
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| author | Yue Huang Zhuo Wang |
| author_facet | Yue Huang Zhuo Wang |
| author_sort | Yue Huang |
| collection | DOAJ |
| description | Background As the worldwide population ages, osteoarthritis has significantly increased. This musculoskeletal condition has become a pressing global health issue and thus, prevention and treatment of osteoarthritis have become the primary focus of domestic and international research. Scholarly investigations of the molecular mechanisms that are related to the occurrence and development of osteoarthritis have shed light on the pathological causes of this condition to a certain extent, providing a foundation for its prevention and treatment. However, further research is necessary to fully understand the critical role of the transcription factor SOX9 in chondrocyte differentiation and the development of osteoarthritis. As a result, there has been widespread interest in SOX transcription factors. While SOX9 has been utilized as a biomarker to indicate the occurrence and prognosis of osteoarthritis, investigations into other members of the SOX family and the development of targeted treatments around SOX9 are still required.Purpose This article considers the impact of the SOX protein on the development and inhibition of osteoarthritis and highlights the need for therapeutic approaches targeting SOX9, as supported by existing research.Results SOX9 can contribute to the process of osteoarthritis through acetylation and ubiquitination modifications. The regulation of the WNT signalling pathway, Nrf2/ARE signalling pathway, NF-κB signalling pathway and SOX9 is implicated in the emergence of osteoarthritis. Non-coding RNA may play a role in the onset and progression of osteoarthritis by modulating various SOX family members, including SOX2, SOX4, SOX5, SOX6, SOX8, SOX9 and SOX11.Conclusion SOX9 has the capability of mitigating the onset and progression of osteoarthritis through means such as medication therapy, stem cell therapy, recombinant adeno-associated virus (rAAV) vector therapy, physical therapy and other approaches. |
| format | Article |
| id | doaj-art-666fcad66979400ca5b4cb459b4dde05 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-666fcad66979400ca5b4cb459b4dde052025-01-31T15:03:49ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2457520Therapeutic potential of SOX family transcription factors in osteoarthritisYue Huang0Zhuo Wang1College of Exercise and Health, Shenyang Sport University, Shenyang, ChinaCollege of Exercise and Health, Shenyang Sport University, Shenyang, ChinaBackground As the worldwide population ages, osteoarthritis has significantly increased. This musculoskeletal condition has become a pressing global health issue and thus, prevention and treatment of osteoarthritis have become the primary focus of domestic and international research. Scholarly investigations of the molecular mechanisms that are related to the occurrence and development of osteoarthritis have shed light on the pathological causes of this condition to a certain extent, providing a foundation for its prevention and treatment. However, further research is necessary to fully understand the critical role of the transcription factor SOX9 in chondrocyte differentiation and the development of osteoarthritis. As a result, there has been widespread interest in SOX transcription factors. While SOX9 has been utilized as a biomarker to indicate the occurrence and prognosis of osteoarthritis, investigations into other members of the SOX family and the development of targeted treatments around SOX9 are still required.Purpose This article considers the impact of the SOX protein on the development and inhibition of osteoarthritis and highlights the need for therapeutic approaches targeting SOX9, as supported by existing research.Results SOX9 can contribute to the process of osteoarthritis through acetylation and ubiquitination modifications. The regulation of the WNT signalling pathway, Nrf2/ARE signalling pathway, NF-κB signalling pathway and SOX9 is implicated in the emergence of osteoarthritis. Non-coding RNA may play a role in the onset and progression of osteoarthritis by modulating various SOX family members, including SOX2, SOX4, SOX5, SOX6, SOX8, SOX9 and SOX11.Conclusion SOX9 has the capability of mitigating the onset and progression of osteoarthritis through means such as medication therapy, stem cell therapy, recombinant adeno-associated virus (rAAV) vector therapy, physical therapy and other approaches.https://www.tandfonline.com/doi/10.1080/07853890.2025.2457520SOX family transcription factorsosteoarthritisosteoarthritis therapyageing |
| spellingShingle | Yue Huang Zhuo Wang Therapeutic potential of SOX family transcription factors in osteoarthritis Annals of Medicine SOX family transcription factors osteoarthritis osteoarthritis therapy ageing |
| title | Therapeutic potential of SOX family transcription factors in osteoarthritis |
| title_full | Therapeutic potential of SOX family transcription factors in osteoarthritis |
| title_fullStr | Therapeutic potential of SOX family transcription factors in osteoarthritis |
| title_full_unstemmed | Therapeutic potential of SOX family transcription factors in osteoarthritis |
| title_short | Therapeutic potential of SOX family transcription factors in osteoarthritis |
| title_sort | therapeutic potential of sox family transcription factors in osteoarthritis |
| topic | SOX family transcription factors osteoarthritis osteoarthritis therapy ageing |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2457520 |
| work_keys_str_mv | AT yuehuang therapeuticpotentialofsoxfamilytranscriptionfactorsinosteoarthritis AT zhuowang therapeuticpotentialofsoxfamilytranscriptionfactorsinosteoarthritis |