A Review on the Role of Human Solute Carriers Transporters in Cancer
ABSTRACT Background and Aim The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over‐expression due to their complex formation w...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70343 |
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| author | Md. Shafiul Hossen Mohammed Shafin Ul Islam Mohammad Yasin Mohammed Ibrahim Abhijit Das |
| author_facet | Md. Shafiul Hossen Mohammed Shafin Ul Islam Mohammad Yasin Mohammed Ibrahim Abhijit Das |
| author_sort | Md. Shafiul Hossen |
| collection | DOAJ |
| description | ABSTRACT Background and Aim The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over‐expression due to their complex formation with other biological molecules. Therefore, this review investigated the role of SLC transporters in the progression of cancer. Methods We retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, and EMBASE regarding the influence of human SLCs on the development of cancer. Articles published in English before August 2024 were included in the study. Results The overexpression of SLCs is strongly related to tumor cell proliferation and angiogenesis in a number of cancer types including thyroid, pancreatic, lung, hepatocellular, and colon cancers. They are crucial for the stimulation of several biological signaling pathways, particularly mTOR kinase activity, which starts a signaling cascade, protein synthesis, cell growth, and proliferation, and inhibits apoptosis of cancerous cells. Furthermore, they contribute to the activation of PI3K/AKT signaling, which has an impact on the growth, invasion, and death of cancer cells. Thus, SLC transporters become a potential therapeutic target that plays a crucial role in drug resistance, tumor microenvironment regulation, and modulation of immune response. Conclusion The review recognized the crucial role of SLC transporters in different types of cancer progression. Therefore, to confirm our findings, a case‐control study is required to investigate the role of amino acid transporters in cancer development. |
| format | Article |
| id | doaj-art-665935934af647909de0a3d1272d5aa8 |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-665935934af647909de0a3d1272d5aa82025-01-29T03:42:40ZengWileyHealth Science Reports2398-88352025-01-0181n/an/a10.1002/hsr2.70343A Review on the Role of Human Solute Carriers Transporters in CancerMd. Shafiul Hossen0Mohammed Shafin Ul Islam1Mohammad Yasin2Mohammed Ibrahim3Abhijit Das4Department of Pharmacy State University of Bangladesh Dhaka BangladeshDepartment of Pharmacy Southern University Bangladesh Chittagong BangladeshDepartment of Pharmacy Southern University Bangladesh Chittagong BangladeshDepartment of Pharmacy State University of Bangladesh Dhaka BangladeshDepartment of Pharmacy Noakhali Science and Technology University Sonapur BangladeshABSTRACT Background and Aim The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over‐expression due to their complex formation with other biological molecules. Therefore, this review investigated the role of SLC transporters in the progression of cancer. Methods We retrieved data from Google Scholar, Web of Science, PubMed, Cochrane Library, and EMBASE regarding the influence of human SLCs on the development of cancer. Articles published in English before August 2024 were included in the study. Results The overexpression of SLCs is strongly related to tumor cell proliferation and angiogenesis in a number of cancer types including thyroid, pancreatic, lung, hepatocellular, and colon cancers. They are crucial for the stimulation of several biological signaling pathways, particularly mTOR kinase activity, which starts a signaling cascade, protein synthesis, cell growth, and proliferation, and inhibits apoptosis of cancerous cells. Furthermore, they contribute to the activation of PI3K/AKT signaling, which has an impact on the growth, invasion, and death of cancer cells. Thus, SLC transporters become a potential therapeutic target that plays a crucial role in drug resistance, tumor microenvironment regulation, and modulation of immune response. Conclusion The review recognized the crucial role of SLC transporters in different types of cancer progression. Therefore, to confirm our findings, a case‐control study is required to investigate the role of amino acid transporters in cancer development.https://doi.org/10.1002/hsr2.70343amino acid transporterscancersolute carriers (SLC)tumor |
| spellingShingle | Md. Shafiul Hossen Mohammed Shafin Ul Islam Mohammad Yasin Mohammed Ibrahim Abhijit Das A Review on the Role of Human Solute Carriers Transporters in Cancer Health Science Reports amino acid transporters cancer solute carriers (SLC) tumor |
| title | A Review on the Role of Human Solute Carriers Transporters in Cancer |
| title_full | A Review on the Role of Human Solute Carriers Transporters in Cancer |
| title_fullStr | A Review on the Role of Human Solute Carriers Transporters in Cancer |
| title_full_unstemmed | A Review on the Role of Human Solute Carriers Transporters in Cancer |
| title_short | A Review on the Role of Human Solute Carriers Transporters in Cancer |
| title_sort | review on the role of human solute carriers transporters in cancer |
| topic | amino acid transporters cancer solute carriers (SLC) tumor |
| url | https://doi.org/10.1002/hsr2.70343 |
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