Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants
Background. Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant. Purpose. To investigate the association of genetic polymorphisms in interleukin- (IL-) 10 [-10...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2017/3901368 |
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| _version_ | 1832550216550580224 |
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| author | Rodrigo Ribeiro Rayanne Melo Pedro Tortamano Neto André Vajgel Paulo Roberto Eleutério Souza Renata Cimões |
| author_facet | Rodrigo Ribeiro Rayanne Melo Pedro Tortamano Neto André Vajgel Paulo Roberto Eleutério Souza Renata Cimões |
| author_sort | Rodrigo Ribeiro |
| collection | DOAJ |
| description | Background. Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant. Purpose. To investigate the association of genetic polymorphisms in interleukin- (IL-) 10 [-1082 region (A/G)] and RANKL [-438 region (A/G)] with the failure of dental implants. Materials and Methods. This study included 90 partially edentulous male and female patients who were rehabilitated with a total of 245 Straumann dental implants. An implant was considered a failure if any of the following occurred: mobility, persistent subjective complaint, recurrent peri-implant infection with suppuration, continuous radiolucency around the implant, probing depth ≥ 5 mm, and bleeding on probing. Buccal mucosal cells were collected for analysis of RANKL438 and IL-10. Results. The implant success rate in this population was 34.4%. The mutant allele (G) in RANKL had an incidence of 52.3% and mutant allele (A) in IL-10 was observed in 37.8%. No statistically significant difference was detected between the failure of the implant and the genotypes and allelic frequencies. Conclusion. No association was detected between the genetic polymorphisms of RANKL (-438) and IL-10 (-1082) and the failure of dental implants in the population studied. |
| format | Article |
| id | doaj-art-664900ad88f64a6fabdd79024123928b |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-664900ad88f64a6fabdd79024123928b2025-02-03T06:07:22ZengWileyInternational Journal of Dentistry1687-87281687-87362017-01-01201710.1155/2017/39013683901368Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental ImplantsRodrigo Ribeiro0Rayanne Melo1Pedro Tortamano Neto2André Vajgel3Paulo Roberto Eleutério Souza4Renata Cimões5Federal University of Campina Grande, Campina Grande, PB, BrazilFederal University of Pernambuco, Recife, PE, BrazilDepartment of Prosthodontics, University of São Paulo, São Paulo, SP, BrazilFederal University of Pernambuco, Recife, PE, BrazilDepartment of Genetics, Rural Federal University of Pernambuco, Recife, PE, BrazilDepartment of Prosthodontics and Oral and Facial Surgery, Federal University of Pernambuco, Recife, PE, BrazilBackground. Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant. Purpose. To investigate the association of genetic polymorphisms in interleukin- (IL-) 10 [-1082 region (A/G)] and RANKL [-438 region (A/G)] with the failure of dental implants. Materials and Methods. This study included 90 partially edentulous male and female patients who were rehabilitated with a total of 245 Straumann dental implants. An implant was considered a failure if any of the following occurred: mobility, persistent subjective complaint, recurrent peri-implant infection with suppuration, continuous radiolucency around the implant, probing depth ≥ 5 mm, and bleeding on probing. Buccal mucosal cells were collected for analysis of RANKL438 and IL-10. Results. The implant success rate in this population was 34.4%. The mutant allele (G) in RANKL had an incidence of 52.3% and mutant allele (A) in IL-10 was observed in 37.8%. No statistically significant difference was detected between the failure of the implant and the genotypes and allelic frequencies. Conclusion. No association was detected between the genetic polymorphisms of RANKL (-438) and IL-10 (-1082) and the failure of dental implants in the population studied.http://dx.doi.org/10.1155/2017/3901368 |
| spellingShingle | Rodrigo Ribeiro Rayanne Melo Pedro Tortamano Neto André Vajgel Paulo Roberto Eleutério Souza Renata Cimões Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants International Journal of Dentistry |
| title | Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants |
| title_full | Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants |
| title_fullStr | Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants |
| title_full_unstemmed | Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants |
| title_short | Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants |
| title_sort | polymorphisms of il 10 1082 and rankl 438 genes and the failure of dental implants |
| url | http://dx.doi.org/10.1155/2017/3901368 |
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