Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation?
Tenosynovial giant cell tumor (TGCT) is a rare mesenchymal tumor that clinically presents as nodular-type or diffuse-type (D-TGCT). D-TGCT is more aggressive, has a higher surgical recurrence rate, and can potentially lead to severe joint destruction. The traditional treatment is primarily through s...
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Magazine House of Cancer Research on Prevention and Treatment
2025-01-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0656 |
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| author | Hairong XU Jing CHEN Xiaohui NIU |
| author_facet | Hairong XU Jing CHEN Xiaohui NIU |
| author_sort | Hairong XU |
| collection | DOAJ |
| description | Tenosynovial giant cell tumor (TGCT) is a rare mesenchymal tumor that clinically presents as nodular-type or diffuse-type (D-TGCT). D-TGCT is more aggressive, has a higher surgical recurrence rate, and can potentially lead to severe joint destruction. The traditional treatment is primarily through surgical intervention. Recent advancements in understanding the molecular mechanisms of the disease and the development of new drugs have significantly changed TGCT treatment strategies. Drug therapy and active surveillance have become important treatment options for unresectable or high-recurrence-risk TGCT. Imaging examinations and patient-reported outcome tools play a crucial role in evaluating efficacy and guiding treatment decisions. Comprehensive management by a multidisciplinary team and utilizing individualized treatment plans can significantly improve the quality of life and treatment outcomes of patients. Future research should explore the molecular mechanisms of TGCT, enhance multidisciplinary collaboration, and emphasize long-term management to improve treatment efficacy and patient prognosis. |
| format | Article |
| id | doaj-art-663f916eb7cc478f9acec73d22bfbb19 |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-663f916eb7cc478f9acec73d22bfbb192025-01-23T07:44:48ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-01-015211610.3971/j.issn.1000-8578.2025.24.065620240656Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation?Hairong XU0Jing CHEN1Xiaohui NIU2Department of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, ChinaDepartment of Sarcoma and Melanoma, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Orthopaedic Oncology Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, ChinaTenosynovial giant cell tumor (TGCT) is a rare mesenchymal tumor that clinically presents as nodular-type or diffuse-type (D-TGCT). D-TGCT is more aggressive, has a higher surgical recurrence rate, and can potentially lead to severe joint destruction. The traditional treatment is primarily through surgical intervention. Recent advancements in understanding the molecular mechanisms of the disease and the development of new drugs have significantly changed TGCT treatment strategies. Drug therapy and active surveillance have become important treatment options for unresectable or high-recurrence-risk TGCT. Imaging examinations and patient-reported outcome tools play a crucial role in evaluating efficacy and guiding treatment decisions. Comprehensive management by a multidisciplinary team and utilizing individualized treatment plans can significantly improve the quality of life and treatment outcomes of patients. Future research should explore the molecular mechanisms of TGCT, enhance multidisciplinary collaboration, and emphasize long-term management to improve treatment efficacy and patient prognosis.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0656tenosynovial giant cell tumortreatment strategiesdrug therapysurgical treatmentradiation therapy |
| spellingShingle | Hairong XU Jing CHEN Xiaohui NIU Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation? Zhongliu Fangzhi Yanjiu tenosynovial giant cell tumor treatment strategies drug therapy surgical treatment radiation therapy |
| title | Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation? |
| title_full | Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation? |
| title_fullStr | Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation? |
| title_full_unstemmed | Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation? |
| title_short | Treatment Choices for Tenosynovial Giant Cell Tumor: Surgery or Observation? |
| title_sort | treatment choices for tenosynovial giant cell tumor surgery or observation |
| topic | tenosynovial giant cell tumor treatment strategies drug therapy surgical treatment radiation therapy |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0656 |
| work_keys_str_mv | AT hairongxu treatmentchoicesfortenosynovialgiantcelltumorsurgeryorobservation AT jingchen treatmentchoicesfortenosynovialgiantcelltumorsurgeryorobservation AT xiaohuiniu treatmentchoicesfortenosynovialgiantcelltumorsurgeryorobservation |