Design, antiproliferative potency, and in silico studies of novel 5-methylfuran-3-yl)thio)-3-phenylquinazolin-4(3H)-one based derivatives as potential EGFR inhibitors

Design, antiproliferative potency, and in silico studies of novel 5-methylfuran-3-yl)thio)-3-phenylquinazolin-4(3H)-one based derivatives as potential EGFR inhibitors

Abstract Quinazolinone derivatives have been broadly studied as anti-cancer drug candidates due to their potential to inhibit key signaling pathways involved in tumor progression. In the current study, new 2-[(4-substituted-5-methylfuran-3-yl)thio]-3-phenylquinazolin-4(3H)-one derivatives (2–10) wer...

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Bibliographic Details
Main Authors: Sara M. Soliman, Adel A.-H. Abdel-Rahman, Eman S. Nossier, Modather F. Hussein, Amr Sabry, Hagar S. El-Hema
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Quinazolin-4-one
Anticancer
EGFR
Molecular docking
ADMET
Quantum calculations
Online Access:https://doi.org/10.1038/s41598-025-12140-1
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