A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/6846721 |
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| author | Maximilian Wiesmann Valerio Zerbi Diane Jansen Roy Haast Dieter Lütjohann Laus M. Broersen Arend Heerschap Amanda J. Kiliaan |
| author_facet | Maximilian Wiesmann Valerio Zerbi Diane Jansen Roy Haast Dieter Lütjohann Laus M. Broersen Arend Heerschap Amanda J. Kiliaan |
| author_sort | Maximilian Wiesmann |
| collection | DOAJ |
| description | APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging. |
| format | Article |
| id | doaj-art-66310479963542e38ccb9d66b05caf7e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-66310479963542e38ccb9d66b05caf7e2025-02-03T06:42:26ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/68467216846721A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 MiceMaximilian Wiesmann0Valerio Zerbi1Diane Jansen2Roy Haast3Dieter Lütjohann4Laus M. Broersen5Arend Heerschap6Amanda J. Kiliaan7Department of Anatomy, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, 6525 EZ Nijmegen, NetherlandsDepartment of Anatomy, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, 6525 EZ Nijmegen, NetherlandsDepartment of Anatomy, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, 6525 EZ Nijmegen, NetherlandsDepartment of Anatomy, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, 6525 EZ Nijmegen, NetherlandsInstitute for Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, GermanyNutricia Research, Advanced Medical Nutrition, Utrecht, NetherlandsDepartment of Radiology and Nuclear Medicine, Radboud University Medical Center, 6525 EZ Nijmegen, NetherlandsDepartment of Anatomy, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, 6525 EZ Nijmegen, NetherlandsAPOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging.http://dx.doi.org/10.1155/2016/6846721 |
| spellingShingle | Maximilian Wiesmann Valerio Zerbi Diane Jansen Roy Haast Dieter Lütjohann Laus M. Broersen Arend Heerschap Amanda J. Kiliaan A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice Neural Plasticity |
| title | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
| title_full | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
| title_fullStr | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
| title_full_unstemmed | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
| title_short | A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice |
| title_sort | dietary treatment improves cerebral blood flow and brain connectivity in aging apoe4 mice |
| url | http://dx.doi.org/10.1155/2016/6846721 |
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