Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study
Background: Systemic alterations in the oral cavity can be reflected in skin disorders like psoriasis. However, data about oral health factors that are affected and controlled mainly by oral microbiota in atopic dermatitis (AD) are sparse. This study compared the oral status and oral microbiota of A...
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Elsevier
2025-02-01
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| Series: | International Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0020653924015508 |
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| author | Aaya Shahin Yael Anne Leshem Yossi Taieb Sharon Baum Aviv Barzilai Danielle Jeddah Efrat Sharon Omry Koren Rinat Tzach-Nahman Shunit Coppenhagen-Glazer Ronen Hazan Yael Houri-Haddad Shoshana Greenberger |
| author_facet | Aaya Shahin Yael Anne Leshem Yossi Taieb Sharon Baum Aviv Barzilai Danielle Jeddah Efrat Sharon Omry Koren Rinat Tzach-Nahman Shunit Coppenhagen-Glazer Ronen Hazan Yael Houri-Haddad Shoshana Greenberger |
| author_sort | Aaya Shahin |
| collection | DOAJ |
| description | Background: Systemic alterations in the oral cavity can be reflected in skin disorders like psoriasis. However, data about oral health factors that are affected and controlled mainly by oral microbiota in atopic dermatitis (AD) are sparse. This study compared the oral status and oral microbiota of AD patients and healthy controls. Methods: This was a prospective sex- and age-matched case-control study comparing adult participants with and without dermatologist-verified AD. A dentist assessed oral health status, and oral flora samples were collected and subjected to 16S rRNA sequencing for microbiome analysis. Results: Forty-five AD participants and 41 non-AD controls were recruited. Compared to the participants in the control group, those with AD had significantly higher plaque levels (P = .04), poorer oral hygiene indices (P = .04), and higher gingival index trends (P = .05). The oral microbiome in the AD group showed significantly higher diversity, both in α and β diversities (P = .001, P = .0007, respectively). Furthermore, AD patients had a significantly increased abundance of taxa correlated with oral diseases and a decreased abundance of bacteria associated with a healthy oral status. Conclusion: AD appears to be associated with poor oral health and oral dysbiosis. There is a need to increase both patients’ and physicians’ awareness of oral health. |
| format | Article |
| id | doaj-art-662bc993e375413299efeb6b5bac0e83 |
| institution | Kabale University |
| issn | 0020-6539 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Dental Journal |
| spelling | doaj-art-662bc993e375413299efeb6b5bac0e832025-01-21T04:12:46ZengElsevierInternational Dental Journal0020-65392025-02-01751279287Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control StudyAaya Shahin0Yael Anne Leshem1Yossi Taieb2Sharon Baum3Aviv Barzilai4Danielle Jeddah5Efrat Sharon6Omry Koren7Rinat Tzach-Nahman8Shunit Coppenhagen-Glazer9Ronen Hazan10Yael Houri-Haddad11Shoshana Greenberger12Department of Prosthodontics, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; Corresponding author. Faculty of Dental Medicine, The Hebrew University-Hadassah, P.O. Box 12272, Jerusalem 91120, Israel.Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel; Faculty of Medicine & Health Sciences, Tel Aviv University, Tel Aviv, IsraelDivision of Dermatology, Rabin Medical Center, Petah Tikva, IsraelFaculty of Medicine & Health Sciences, Tel Aviv University, Tel Aviv, Israel; The Department of Dermatology, Sheba Medical Center, Ramat Gan, IsraelFaculty of Medicine & Health Sciences, Tel Aviv University, Tel Aviv, Israel; The Department of Dermatology, Sheba Medical Center, Ramat Gan, IsraelFaculty of Medicine & Health Sciences, Tel Aviv University, Tel Aviv, IsraelAzrieli Faculty of Medicine, Bar-Ilan University, Safed, IsraelAzrieli Faculty of Medicine, Bar-Ilan University, Safed, IsraelDepartment of Prosthodontics, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelInstitute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelDepartment of Prosthodontics, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelFaculty of Medicine & Health Sciences, Tel Aviv University, Tel Aviv, Israel; The Department of Dermatology, Pediatric Dermatology Service, Sheba Medical Center, Ramat Gan, IsraelBackground: Systemic alterations in the oral cavity can be reflected in skin disorders like psoriasis. However, data about oral health factors that are affected and controlled mainly by oral microbiota in atopic dermatitis (AD) are sparse. This study compared the oral status and oral microbiota of AD patients and healthy controls. Methods: This was a prospective sex- and age-matched case-control study comparing adult participants with and without dermatologist-verified AD. A dentist assessed oral health status, and oral flora samples were collected and subjected to 16S rRNA sequencing for microbiome analysis. Results: Forty-five AD participants and 41 non-AD controls were recruited. Compared to the participants in the control group, those with AD had significantly higher plaque levels (P = .04), poorer oral hygiene indices (P = .04), and higher gingival index trends (P = .05). The oral microbiome in the AD group showed significantly higher diversity, both in α and β diversities (P = .001, P = .0007, respectively). Furthermore, AD patients had a significantly increased abundance of taxa correlated with oral diseases and a decreased abundance of bacteria associated with a healthy oral status. Conclusion: AD appears to be associated with poor oral health and oral dysbiosis. There is a need to increase both patients’ and physicians’ awareness of oral health.http://www.sciencedirect.com/science/article/pii/S0020653924015508MicrobiotaSkin diseasesPeriodontitisDental cariesGingivitisOral hygiene |
| spellingShingle | Aaya Shahin Yael Anne Leshem Yossi Taieb Sharon Baum Aviv Barzilai Danielle Jeddah Efrat Sharon Omry Koren Rinat Tzach-Nahman Shunit Coppenhagen-Glazer Ronen Hazan Yael Houri-Haddad Shoshana Greenberger Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study International Dental Journal Microbiota Skin diseases Periodontitis Dental caries Gingivitis Oral hygiene |
| title | Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study |
| title_full | Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study |
| title_fullStr | Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study |
| title_full_unstemmed | Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study |
| title_short | Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study |
| title_sort | association of adult atopic dermatitis with impaired oral health and oral dysbiosis a case control study |
| topic | Microbiota Skin diseases Periodontitis Dental caries Gingivitis Oral hygiene |
| url | http://www.sciencedirect.com/science/article/pii/S0020653924015508 |
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