Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics

Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics

The PI3K/AKT/mTOR pathway is central in regulating key cellular processes such as proliferation, survival, metabolism, and angiogenesis. Dysregulation of this pathway, particularly in the AKT2 isoform, is commonly observed in cancers such as breast, ovarian, and pancreatic cancers, leading to enhanc...

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Bibliographic Details
Main Authors: Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
ATK2
Molecular docking
Molecular dynamics simulation
Uzarigenin
Oncogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025002774
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