Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer
Osteogenesis imperfecta (OI) is a rare, inherited skeletal disorder characterized by abnormalities of type 1 collagen. Malignancy is rarely reported in patients with OI and it was suggested that this disease can protect against cancer. Here, we report a 41-year-old woman with symptoms of achalasia w...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/685459 |
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| _version_ | 1832551610022100992 |
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| author | Dilsa Mizrak Ali Alkan Batuhan Erdogdu Gungor Utkan |
| author_facet | Dilsa Mizrak Ali Alkan Batuhan Erdogdu Gungor Utkan |
| author_sort | Dilsa Mizrak |
| collection | DOAJ |
| description | Osteogenesis imperfecta (OI) is a rare, inherited skeletal disorder characterized by abnormalities of type 1 collagen. Malignancy is rarely reported in patients with OI and it was suggested that this disease can protect against cancer. Here, we report a 41-year-old woman with symptoms of achalasia where repeated treatment of pneumatic dilation and stent replacement was unsuccessful; therefore, surgery was performed. Pathology showed gastric adenocarcinoma unexpectedly. Chemotherapy was given after assessing dihydropyrimidine dehydrogenase (DPD) enzyme activity, which can be deficient in OI patients. This is the first report of gastric cancer mimicking achalasia in a patient with OI. |
| format | Article |
| id | doaj-art-6603599d16ec41618eb15dfbb447e74d |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-6603599d16ec41618eb15dfbb447e74d2025-02-03T06:01:02ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362015-01-01201510.1155/2015/685459685459Osteogenesis Imperfecta, Pseudoachalasia, and Gastric CancerDilsa Mizrak0Ali Alkan1Batuhan Erdogdu2Gungor Utkan3Department of Medical Oncology, Ankara University School of Medicine, 06300 Ankara, TurkeyDepartment of Medical Oncology, Ankara University School of Medicine, 06300 Ankara, TurkeyDepartment of Internal Medicine, Ankara University School of Medicine, 06300 Ankara, TurkeyDepartment of Medical Oncology, Ankara University School of Medicine, 06300 Ankara, TurkeyOsteogenesis imperfecta (OI) is a rare, inherited skeletal disorder characterized by abnormalities of type 1 collagen. Malignancy is rarely reported in patients with OI and it was suggested that this disease can protect against cancer. Here, we report a 41-year-old woman with symptoms of achalasia where repeated treatment of pneumatic dilation and stent replacement was unsuccessful; therefore, surgery was performed. Pathology showed gastric adenocarcinoma unexpectedly. Chemotherapy was given after assessing dihydropyrimidine dehydrogenase (DPD) enzyme activity, which can be deficient in OI patients. This is the first report of gastric cancer mimicking achalasia in a patient with OI.http://dx.doi.org/10.1155/2015/685459 |
| spellingShingle | Dilsa Mizrak Ali Alkan Batuhan Erdogdu Gungor Utkan Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer Case Reports in Gastrointestinal Medicine |
| title | Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer |
| title_full | Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer |
| title_fullStr | Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer |
| title_full_unstemmed | Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer |
| title_short | Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer |
| title_sort | osteogenesis imperfecta pseudoachalasia and gastric cancer |
| url | http://dx.doi.org/10.1155/2015/685459 |
| work_keys_str_mv | AT dilsamizrak osteogenesisimperfectapseudoachalasiaandgastriccancer AT alialkan osteogenesisimperfectapseudoachalasiaandgastriccancer AT batuhanerdogdu osteogenesisimperfectapseudoachalasiaandgastriccancer AT gungorutkan osteogenesisimperfectapseudoachalasiaandgastriccancer |