Dynamic mechanisms and targeted interventions in cerebral ischemia–reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies

Dynamic mechanisms and targeted interventions in cerebral ischemia–reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies

Cerebral ischemia–reperfusion injury (CI/RI) is a critical event causing secondary neurological deterioration following vascular recanalization in patients with ischemic stroke (IS), involving multiple interrelated pathological processes that synergistically aggravate brain injury. However, the unde...

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Bibliographic Details
Main Authors: Xufeng Meng, Zhi Zheng, Li Yang, Chen Yang, Xiaoli Li, Yunfei Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Neuroscience
Subjects:
cerebral ischemia reperfusion injury (CI/RI)
ischemic stroke (IS)
pathologic process
mitochondrial dysfunction
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1649533/full
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