Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after Resection
Serum levels of the tumor marker CA19-9 have been reported to be elevated in patients with hepatocellular carcinoma (HCC), but its clinicopathologic significance is still unknown. A cohort of 304 patients undergoing surgical resection for HCC and having preoperative CA19-9 data was enrolled in this...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/380797 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567590237503488 |
|---|---|
| author | Yu-Ling Chen Chien-Hung Chen Rey-Heng Hu Ming-Chih Ho Yung-Ming Jeng |
| author_facet | Yu-Ling Chen Chien-Hung Chen Rey-Heng Hu Ming-Chih Ho Yung-Ming Jeng |
| author_sort | Yu-Ling Chen |
| collection | DOAJ |
| description | Serum levels of the tumor marker CA19-9 have been reported to be elevated in patients with hepatocellular carcinoma (HCC), but its clinicopathologic significance is still unknown. A cohort of 304 patients undergoing surgical resection for HCC and having preoperative CA19-9 data was enrolled in this study. Serum CA19-9 levels were correlated with clinicopathologic factors. Univariate and multivariate analyses were performed to determine the predictors of patient survival. On receiver operating characteristic curve analysis, the cut off value of CA19-9 was determined to be 27 U/mL. One hundred and six patients had preoperative CA19-9 values >27 U/mL. High serum CA19-9 levels did not correlate with patient age, sex, viral status, α-fetoprotein level, tumor size, tumor grade, tumor stage, multiplicity, and vascular invasion. Patients with elevated preoperative CA19-9 levels had lower 10-year survival than those without CA19-9 elevation. Multivariate analysis revealed that CA19-9 level, tumor grade, and tumor size are independent prognostic factors for long-term survival. In conclusion, a preoperative CA19-9 value >27 U/mL is associated with poor prognosis after resection for HCC. |
| format | Article |
| id | doaj-art-65fa40444d1a41269c2e92b8beed5db2 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-65fa40444d1a41269c2e92b8beed5db22025-02-03T01:01:10ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/380797380797Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after ResectionYu-Ling Chen0Chien-Hung Chen1Rey-Heng Hu2Ming-Chih Ho3Yung-Ming Jeng4Graduate Institute of Pathology, National Taiwan University, Taipei 100, TaiwanDepartment of Medicine, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Surgery, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Pathology, National Taiwan University Hospital, Taipei 100, TaiwanGraduate Institute of Pathology, National Taiwan University, Taipei 100, TaiwanSerum levels of the tumor marker CA19-9 have been reported to be elevated in patients with hepatocellular carcinoma (HCC), but its clinicopathologic significance is still unknown. A cohort of 304 patients undergoing surgical resection for HCC and having preoperative CA19-9 data was enrolled in this study. Serum CA19-9 levels were correlated with clinicopathologic factors. Univariate and multivariate analyses were performed to determine the predictors of patient survival. On receiver operating characteristic curve analysis, the cut off value of CA19-9 was determined to be 27 U/mL. One hundred and six patients had preoperative CA19-9 values >27 U/mL. High serum CA19-9 levels did not correlate with patient age, sex, viral status, α-fetoprotein level, tumor size, tumor grade, tumor stage, multiplicity, and vascular invasion. Patients with elevated preoperative CA19-9 levels had lower 10-year survival than those without CA19-9 elevation. Multivariate analysis revealed that CA19-9 level, tumor grade, and tumor size are independent prognostic factors for long-term survival. In conclusion, a preoperative CA19-9 value >27 U/mL is associated with poor prognosis after resection for HCC.http://dx.doi.org/10.1155/2013/380797 |
| spellingShingle | Yu-Ling Chen Chien-Hung Chen Rey-Heng Hu Ming-Chih Ho Yung-Ming Jeng Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after Resection The Scientific World Journal |
| title | Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after Resection |
| title_full | Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after Resection |
| title_fullStr | Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after Resection |
| title_full_unstemmed | Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after Resection |
| title_short | Elevated Preoperative Serum CA19-9 Levels in Patients with Hepatocellular Carcinoma Is Associated with Poor Prognosis after Resection |
| title_sort | elevated preoperative serum ca19 9 levels in patients with hepatocellular carcinoma is associated with poor prognosis after resection |
| url | http://dx.doi.org/10.1155/2013/380797 |
| work_keys_str_mv | AT yulingchen elevatedpreoperativeserumca199levelsinpatientswithhepatocellularcarcinomaisassociatedwithpoorprognosisafterresection AT chienhungchen elevatedpreoperativeserumca199levelsinpatientswithhepatocellularcarcinomaisassociatedwithpoorprognosisafterresection AT reyhenghu elevatedpreoperativeserumca199levelsinpatientswithhepatocellularcarcinomaisassociatedwithpoorprognosisafterresection AT mingchihho elevatedpreoperativeserumca199levelsinpatientswithhepatocellularcarcinomaisassociatedwithpoorprognosisafterresection AT yungmingjeng elevatedpreoperativeserumca199levelsinpatientswithhepatocellularcarcinomaisassociatedwithpoorprognosisafterresection |