Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China
Background As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of...
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BMJ Publishing Group
2025-04-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/38/2/e101736.full |
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| author | Wei Chen Yuanyuan Liu Xulai Zhang Juan Li Ying Liu ChenCheng Zhang Shifu Xiao Tao Wang Yong Lu Huali Wang Yiru Fang Yuping Wang Feng Yan Ning Su Haining He Yanchen Shi Minjie Zhu Muni Tang Feng Bao Yefeng Yuan Xiaoyun Zuo Lijuan Cui Wenyuan Wu |
| author_facet | Wei Chen Yuanyuan Liu Xulai Zhang Juan Li Ying Liu ChenCheng Zhang Shifu Xiao Tao Wang Yong Lu Huali Wang Yiru Fang Yuping Wang Feng Yan Ning Su Haining He Yanchen Shi Minjie Zhu Muni Tang Feng Bao Yefeng Yuan Xiaoyun Zuo Lijuan Cui Wenyuan Wu |
| author_sort | Wei Chen |
| collection | DOAJ |
| description | Background As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.Aims To estimate the prevalence and incidence rates of two MCI subtypes—amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)—and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.Method This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively.Results Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.Conclusions MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.Trial registration number NCT03672448. |
| format | Article |
| id | doaj-art-65f0a91c4ffd42a8a74fdb8cd3388064 |
| institution | OA Journals |
| issn | 2517-729X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMJ Publishing Group |
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| series | General Psychiatry |
| spelling | doaj-art-65f0a91c4ffd42a8a74fdb8cd33880642025-08-20T02:28:04ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2025-04-0138210.1136/gpsych-2024-101736Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in ChinaWei Chen0Yuanyuan Liu1Xulai Zhang2Juan Li3Ying Liu4ChenCheng Zhang5Shifu Xiao6Tao Wang7Yong Lu8Huali Wang9Yiru Fang10Yuping Wang11Feng Yan12Ning Su13Haining He14Yanchen Shi15Minjie Zhu16Muni Tang17Feng Bao18Yefeng Yuan19Xiaoyun Zuo20Lijuan Cui21Wenyuan Wu22chest physician2 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China14 The Fourth People’s Hospital of Hefei City, Hefei, Anhui, China5 Institute of Psychology, Chinese Academy of Sciences, Beijing, China11 The First Affiliated Hospital of the China Medical University, Shenyang, Liaoning, China17 Department of Neurosurgery, Clinical Neuroscience Center Comprehensive Epilepsy Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China2 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China1 Department of Neurology and Department of Psychiatry, Wuxi Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, ChinaDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China9 Institute of Mental Health, Peking University, Beijing, China20 Department of Psychiatry and Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China10 Xuanwu Hospital, Capital Medical University, Beijing, China2 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China2 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China4 Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China2 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China2 Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China6 Guangzhou Brain Hospital, Guangzhou, Guangdong, China8 Anding Hospital, Capital Medical University, Beijing, China12 The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China13 The Third People’s Hospital of Ji’an City, Ji’an, Jiangxi, China15 East China Normal University, Shanghai, China16 Tongji Hospital, Tongji University, Shanghai, ChinaBackground As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.Aims To estimate the prevalence and incidence rates of two MCI subtypes—amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)—and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.Method This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively.Results Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.Conclusions MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.Trial registration number NCT03672448.https://gpsych.bmj.com/content/38/2/e101736.full |
| spellingShingle | Wei Chen Yuanyuan Liu Xulai Zhang Juan Li Ying Liu ChenCheng Zhang Shifu Xiao Tao Wang Yong Lu Huali Wang Yiru Fang Yuping Wang Feng Yan Ning Su Haining He Yanchen Shi Minjie Zhu Muni Tang Feng Bao Yefeng Yuan Xiaoyun Zuo Lijuan Cui Wenyuan Wu Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China General Psychiatry |
| title | Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China |
| title_full | Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China |
| title_fullStr | Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China |
| title_full_unstemmed | Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China |
| title_short | Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China |
| title_sort | prevalence incidence and modifiable factors for subtypes of mild cognitive impairment results from the longitudinal ageing study in china |
| url | https://gpsych.bmj.com/content/38/2/e101736.full |
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