Development of a T cell engaging bispecific antibody targeting long non-coding RNA PVT1

Development of a T cell engaging bispecific antibody targeting long non-coding RNA PVT1

Abstract The development of effective immunotherapies for solid tumors remains a significant challenge. In previous studies, we identified PVT1, a long non-coding RNA, with the peptide HF10 derived from PVT1, presented by HLA-A24. This study aims to develop a single-chain variable fragment (scFv) th...

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Bibliographic Details
Main Authors: Hirotaka Kato, Tomohide Tsukahara, Kenji Murata, Hiromu Nishikata, Yuka Mizue, Takashi Sasaya, Terufumi Kubo, Takayuki Kanaseki, Yoshihiko Hirohashi, Atsushi Oyagi, Tatsuo Maeda, Akihiro Miyazaki, Toshihiko Torigoe
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Long non-coding RNA
Osteosarcoma
Carcinoma
HLA-A24
CTL epitope
Peptide
Online Access:https://doi.org/10.1007/s00262-025-03976-7
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