A percolation theory analysis of continuous functional paths in protein sequence space affirms previous insights on the optimization of proteins for adaptability.
A key question in protein evolution and protein engineering is the prevalence of evolutionary paths between distinct proteins. An evolutionary path corresponds to a continuous path of functional sequences in sequence space leading from one protein to another. Natural selection could direct a mutatin...
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0314929 |
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