Delta opioid peptide [D-ala2, D-leu5]-Enkephalin’s ability to enhance mitophagy via TRPV4 to relieve ischemia/reperfusion injury in brain microvascular endothelial cells

Delta opioid peptide [D-ala2, D-leu5]-Enkephalin’s ability to enhance mitophagy via TRPV4 to relieve ischemia/reperfusion injury in brain microvascular endothelial cells

Background Local brain tissue can suffer from ischaemia/reperfusion (I/R) injury, which lead to vascular endothelial damage. The peptide δ opioid receptor (δOR) agonist [D-ala2, D-leu5]-Enkephalin (DADLE) can reduce apoptosis caused by acute I/R injury in brain microvascular endothelial cells (BMECs...

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Main Authors: Xiaoyu Chen, Ran Zhang, Bing Shen, Yang Fang, Zhongfang Deng, Lingchao Kong, Jizheng Guo, Lesha Zhang
Format: Article
Language:English
Published: BMJ Publishing Group
Series:Stroke and Vascular Neurology
Online Access:https://svn.bmj.com/content/early/2024/05/02/svn-2023-003080.full
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https://svn.bmj.com/content/early/2024/05/02/svn-2023-003080.full

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