Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult
Background. Infections are an important cause of morbidity and mortality for acute lymphoblastic leukemia (ALL). However, the reports regarding risk factors of induction-related infection are roughly unknown/limited in adult T-ALL during induction chemotherapy. Methods. We performed a retrospective...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/8867760 |
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| author | Kangyu Huang Min Dai Qiuli Li Nannan Liu Dainan Lin Qiang Wang Xuan Zhou Zhixiang Wang Ya Gao Hua Jin Xiaoli Liu Qifa Liu Hongsheng Zhou |
| author_facet | Kangyu Huang Min Dai Qiuli Li Nannan Liu Dainan Lin Qiang Wang Xuan Zhou Zhixiang Wang Ya Gao Hua Jin Xiaoli Liu Qifa Liu Hongsheng Zhou |
| author_sort | Kangyu Huang |
| collection | DOAJ |
| description | Background. Infections are an important cause of morbidity and mortality for acute lymphoblastic leukemia (ALL). However, the reports regarding risk factors of induction-related infection are roughly unknown/limited in adult T-ALL during induction chemotherapy. Methods. We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive T-ALL patients (N=97) enrolled in a PDT-ALL-LBL clinical trial. Of 97 patients with T-ALL enrolled in the trial, 46 were early T-cell precursor (ETP) ALL and 51 were non-ETP ALL. Results. When compared with non-ETP, ETP ALL subtype was characterized with lower neutrophil count (1.35×109/L vs. 8.7×109/L, P<0.001) and lower myeloid percentage in the bone marrow (13.35% vs. 35.31%, P=0.007). Additionally, ETP ALL had longer neutropenia before diagnosis (P<0.001), as well as during induction chemotherapy (P<0.001). Notably, the ETP cohort experienced higher cumulative incidence of clinically documented infections (CDI; 33.33%, P=0.001), microbiologically documented infections (MDI; 45.24%, P=0.006), resistant infection (11.9%, P=0.013), and mixed infection (21.43%, P=0.003), respectively, than those of the non-ETP cohort. Furthermore, multivariable analysis revealed that T-ALL mixed infection was more likely related to chemotherapy response (OR, 0.025; 95% CI 0.127-0.64; P=0.012) and identified myeloid percentage as a predictor associated with ETP-ALL mixed infection (OR, 0.915; 95% CI 0.843-0.993; P=0.033), with ROC-defined cut-off value of 2.24% in ETP cohorts. Conclusions. Our data for the first time demonstrated that ETP-ALL characterized with impaired myelopoiesis were more susceptible to induction-related infection among T-ALL populations. |
| format | Article |
| id | doaj-art-65de36f289e443d4a41d17dc5ed44574 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-65de36f289e443d4a41d17dc5ed445742025-02-03T05:51:11ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/88677608867760Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in AdultKangyu Huang0Min Dai1Qiuli Li2Nannan Liu3Dainan Lin4Qiang Wang5Xuan Zhou6Zhixiang Wang7Ya Gao8Hua Jin9Xiaoli Liu10Qifa Liu11Hongsheng Zhou12Department of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaDepartment of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, ChinaBackground. Infections are an important cause of morbidity and mortality for acute lymphoblastic leukemia (ALL). However, the reports regarding risk factors of induction-related infection are roughly unknown/limited in adult T-ALL during induction chemotherapy. Methods. We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive T-ALL patients (N=97) enrolled in a PDT-ALL-LBL clinical trial. Of 97 patients with T-ALL enrolled in the trial, 46 were early T-cell precursor (ETP) ALL and 51 were non-ETP ALL. Results. When compared with non-ETP, ETP ALL subtype was characterized with lower neutrophil count (1.35×109/L vs. 8.7×109/L, P<0.001) and lower myeloid percentage in the bone marrow (13.35% vs. 35.31%, P=0.007). Additionally, ETP ALL had longer neutropenia before diagnosis (P<0.001), as well as during induction chemotherapy (P<0.001). Notably, the ETP cohort experienced higher cumulative incidence of clinically documented infections (CDI; 33.33%, P=0.001), microbiologically documented infections (MDI; 45.24%, P=0.006), resistant infection (11.9%, P=0.013), and mixed infection (21.43%, P=0.003), respectively, than those of the non-ETP cohort. Furthermore, multivariable analysis revealed that T-ALL mixed infection was more likely related to chemotherapy response (OR, 0.025; 95% CI 0.127-0.64; P=0.012) and identified myeloid percentage as a predictor associated with ETP-ALL mixed infection (OR, 0.915; 95% CI 0.843-0.993; P=0.033), with ROC-defined cut-off value of 2.24% in ETP cohorts. Conclusions. Our data for the first time demonstrated that ETP-ALL characterized with impaired myelopoiesis were more susceptible to induction-related infection among T-ALL populations.http://dx.doi.org/10.1155/2020/8867760 |
| spellingShingle | Kangyu Huang Min Dai Qiuli Li Nannan Liu Dainan Lin Qiang Wang Xuan Zhou Zhixiang Wang Ya Gao Hua Jin Xiaoli Liu Qifa Liu Hongsheng Zhou Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult Mediators of Inflammation |
| title | Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult |
| title_full | Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult |
| title_fullStr | Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult |
| title_full_unstemmed | Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult |
| title_short | Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult |
| title_sort | early t cell precursor leukemia has a higher risk of induction related infection among t cell acute lymphoblastic leukemia in adult |
| url | http://dx.doi.org/10.1155/2020/8867760 |
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