Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study
Abstract Objectives Transbronchial lung cryobiopsy (TBLC) has been identified to be a new technique to diagnosis interstitial lung disease (ILD). The study was conducted to investigate the safety and the diagnostic accuracy of TBLC contrast with transbronchial lung biosy (TBLB) in patients with ILD....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-025-02435-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849773975166517248 |
|---|---|
| author | Min Yu Xuefeng Xu Xiaoyan Xin Shangwen Yang Yihua Wang Yonglong Xiao Shenyun Shi Xuebing Feng |
| author_facet | Min Yu Xuefeng Xu Xiaoyan Xin Shangwen Yang Yihua Wang Yonglong Xiao Shenyun Shi Xuebing Feng |
| author_sort | Min Yu |
| collection | DOAJ |
| description | Abstract Objectives Transbronchial lung cryobiopsy (TBLC) has been identified to be a new technique to diagnosis interstitial lung disease (ILD). The study was conducted to investigate the safety and the diagnostic accuracy of TBLC contrast with transbronchial lung biosy (TBLB) in patients with ILD. Methods In a cross-sectional and comparative study, patients with suspected ILD who underwent TBLC or TBLB were evaluated from June 2018 to September 2022 in Nanjing drum tower hospital. TBLC and TBLB procedure details and clinical multidisciplinary discussion (MDD) diagnosis based on clinical, radiological, and histopathological information were retrospectively analyzed. Diagnostic yield and complications of TBLC and TBLB were evaluated. Results 187 patients who underwent TBLC and 176 patients who underwent TBLB following a standardized protocol were enrolled. The diagnostic yield of TBLC and TBLB in patients with ILD were 85.0% and 63.1%, respectively. In TBLC, 162 patients (86.6%) had no or mild bleeding and 25 patients (13.4%) had moderate bleeding. None of the patients had severe bleeding and the rate of pneumothorax was 14.4%. Comparatively, pooled incidences of complications were 91.5% for no or mild bleeding, 8.5% for moderate bleeding and 5.1% for pneumothorax after TBLB. There was no difference in the occurrence of bleeding among TBLC group and TBLB group. Conclusions This study indicated that the clinical applicability of TBLC in ILD diagnostic algorithms, with a diagnostic yield of 85.0% and an acceptable safety profile. |
| format | Article |
| id | doaj-art-65c1c920b8bb40baa1b2cbfd3084014f |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-65c1c920b8bb40baa1b2cbfd3084014f2025-08-20T03:01:54ZengBMCEuropean Journal of Medical Research2047-783X2025-03-013011710.1186/s40001-025-02435-4Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative studyMin Yu0Xuefeng Xu1Xiaoyan Xin2Shangwen Yang3Yihua Wang4Yonglong Xiao5Shenyun Shi6Xuebing Feng7Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical UniversityDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical UniversityDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical UniversityDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineAbstract Objectives Transbronchial lung cryobiopsy (TBLC) has been identified to be a new technique to diagnosis interstitial lung disease (ILD). The study was conducted to investigate the safety and the diagnostic accuracy of TBLC contrast with transbronchial lung biosy (TBLB) in patients with ILD. Methods In a cross-sectional and comparative study, patients with suspected ILD who underwent TBLC or TBLB were evaluated from June 2018 to September 2022 in Nanjing drum tower hospital. TBLC and TBLB procedure details and clinical multidisciplinary discussion (MDD) diagnosis based on clinical, radiological, and histopathological information were retrospectively analyzed. Diagnostic yield and complications of TBLC and TBLB were evaluated. Results 187 patients who underwent TBLC and 176 patients who underwent TBLB following a standardized protocol were enrolled. The diagnostic yield of TBLC and TBLB in patients with ILD were 85.0% and 63.1%, respectively. In TBLC, 162 patients (86.6%) had no or mild bleeding and 25 patients (13.4%) had moderate bleeding. None of the patients had severe bleeding and the rate of pneumothorax was 14.4%. Comparatively, pooled incidences of complications were 91.5% for no or mild bleeding, 8.5% for moderate bleeding and 5.1% for pneumothorax after TBLB. There was no difference in the occurrence of bleeding among TBLC group and TBLB group. Conclusions This study indicated that the clinical applicability of TBLC in ILD diagnostic algorithms, with a diagnostic yield of 85.0% and an acceptable safety profile.https://doi.org/10.1186/s40001-025-02435-4Interstitial lung diseaseDiagnostic accuracyTransbronchial lung cryobiopsyTransbronchial lung biosyComplication |
| spellingShingle | Min Yu Xuefeng Xu Xiaoyan Xin Shangwen Yang Yihua Wang Yonglong Xiao Shenyun Shi Xuebing Feng Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study European Journal of Medical Research Interstitial lung disease Diagnostic accuracy Transbronchial lung cryobiopsy Transbronchial lung biosy Complication |
| title | Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study |
| title_full | Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study |
| title_fullStr | Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study |
| title_full_unstemmed | Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study |
| title_short | Transbronchial lung cryobiopsy for diagnosing interstitial lung disease: a cross-sectional, comparative study |
| title_sort | transbronchial lung cryobiopsy for diagnosing interstitial lung disease a cross sectional comparative study |
| topic | Interstitial lung disease Diagnostic accuracy Transbronchial lung cryobiopsy Transbronchial lung biosy Complication |
| url | https://doi.org/10.1186/s40001-025-02435-4 |
| work_keys_str_mv | AT minyu transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy AT xuefengxu transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy AT xiaoyanxin transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy AT shangwenyang transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy AT yihuawang transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy AT yonglongxiao transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy AT shenyunshi transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy AT xuebingfeng transbronchiallungcryobiopsyfordiagnosinginterstitiallungdiseaseacrosssectionalcomparativestudy |