Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model

Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model

Abstract Background The aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathological features associated with neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. These proteins possess a prion-like property, enabling their...

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Bibliographic Details
Main Authors: Douglas M. Lopes, Jack A. Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K. Llewellyn, Zeshan Ahmed, Mark F. Lythgoe, Ian F. Harrison
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Glymphatic
Tau
Propagation
Neurodegeneration
MRI
Online Access:https://doi.org/10.1186/s13195-024-01439-2
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