The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour
Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/967629 |
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| author | Lynne Sykes David A. MacIntyre Xiao J. Yap Tiong Ghee Teoh Phillip R. Bennett |
| author_facet | Lynne Sykes David A. MacIntyre Xiao J. Yap Tiong Ghee Teoh Phillip R. Bennett |
| author_sort | Lynne Sykes |
| collection | DOAJ |
| description | Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes. |
| format | Article |
| id | doaj-art-65be750a73934d30bac9b54fdf66613c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-65be750a73934d30bac9b54fdf66613c2025-02-03T01:02:51ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/967629967629The Th1:Th2 Dichotomy of Pregnancy and Preterm LabourLynne Sykes0David A. MacIntyre1Xiao J. Yap2Tiong Ghee Teoh3Phillip R. Bennett4Parturition Research Group, Department of Surgery and Cancer, Institute of Reproduction and Developmental Biology, Imperial College London, London W12 0NN, UKParturition Research Group, Department of Surgery and Cancer, Institute of Reproduction and Developmental Biology, Imperial College London, London W12 0NN, UKParturition Research Group, Department of Surgery and Cancer, Institute of Reproduction and Developmental Biology, Imperial College London, London W12 0NN, UKSt Mary's Hospital, Imperial College Healthcare NHS Trust, London W1 2NY, UKParturition Research Group, Department of Surgery and Cancer, Institute of Reproduction and Developmental Biology, Imperial College London, London W12 0NN, UKPregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintenance. The majority of publications that report on aberrant Th1:Th2 balance focus on early pregnancy loss and preeclampsia. Over the last few decades, there has been an increased awareness of the role of infection and inflammation in preterm labour, and the search for new biomarkers to predict preterm labour continues. In this paper, we explore the evidence for an aberrant Th1:Th2 profile associated with preterm labour. We also consider the potential for its use in screening women at high risk of preterm labour and for prophylactic therapeutic measures for the prevention of preterm labour and associated neonatal adverse outcomes.http://dx.doi.org/10.1155/2012/967629 |
| spellingShingle | Lynne Sykes David A. MacIntyre Xiao J. Yap Tiong Ghee Teoh Phillip R. Bennett The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour Mediators of Inflammation |
| title | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
| title_full | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
| title_fullStr | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
| title_full_unstemmed | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
| title_short | The Th1:Th2 Dichotomy of Pregnancy and Preterm Labour |
| title_sort | th1 th2 dichotomy of pregnancy and preterm labour |
| url | http://dx.doi.org/10.1155/2012/967629 |
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