Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations.

Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations.

Interferon Regulatory Factor 1 (IRF-1) is a member of the IRF family of transcription factors, which have key and diverse roles in the gene-regulatory networks of the immune system. IRF-1 has been described as a critical mediator of IFN-gamma signalling and as the major player in driving TH1 type re...

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Main Authors: Valentina D Mangano, Taane G Clark, Sarah Auburn, Susana Campino, Mahamadou Diakite, Andrew E Fry, Angela Green, Anna Richardson, Muminatou Jallow, Fatou Sisay-Joof, Margaret Pinder, Michael J Griffiths, Charles Newton, Norbert Peshu, Thomas N Williams, Kevin Marsh, Malcolm E Molyneux, Terrie E Taylor, David Modiano, Dominic P Kwiatkowski, Kirk A Rockett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004206&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004206&type=printable

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