Intestinal parasitic infection among the HIV-infected patients in Nepal
Introduction: Intestinal parasitic infection has been a significant problem in HIV patients, worldwide. In this study, we aimed to measure the prevalence and identify the factors associated with intestinal parasitic infection in people infected with HIV and attending National Public Health Laborato...
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The Journal of Infection in Developing Countries
2013-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/2785 |
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| author | Bishnu Raj Tiwari Prakash Ghimire Sarala Malla Bimala Sharma Surendra Karki |
| author_facet | Bishnu Raj Tiwari Prakash Ghimire Sarala Malla Bimala Sharma Surendra Karki |
| author_sort | Bishnu Raj Tiwari |
| collection | DOAJ |
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Introduction: Intestinal parasitic infection has been a significant problem in HIV patients, worldwide. In this study, we aimed to measure the prevalence and identify the factors associated with intestinal parasitic infection in people infected with HIV and attending National Public Health Laboratory in Kathmandu, Nepal, for CD4 T-cell count.
Methodology: An analytical cross-sectional study in 745 HIV-infected people attending for CD4 T-cell count was conducted.
Results: The prevalence of intestinal parasitic infection was 22.4% (95% CI 19.5 to 25.5). In univariate analysis, age, sex, longer time since diagnosis of HIV, CD4 T-cell count of <200/µL, diarrhoea, marital status, and being under tuberculosis (TB) treatment were significantly associated with increased odds of intestinal parasite infection. However, in the logistic regression model, only the CD4 T-cell count of <200/µL (adjusted OR=4.2, 95% CI 2.5 to 7.0), diarrhoea (adjusted OR=2.8, 95% CI 1.8 to 4.3) and being under TB treatment (adjusted OR=2.9, 95% CI 1.8 to 4.6) remained as significant predictors. On stratification, CD4 T-cell count of <200/ µL was independently associated with higher odds of protozoal as well as helminthes infection. The parasites Cryptosporidium and Cyclospora were observed only in participants with CD4 T-cell counts <200/µL.
Conclusions: Both protozoal and helminthic intestinal parasitic infections are common in HIV-infected people seeking care in healthcare facilities. The poor immune status as indicated by low CD4 T-cell count and TB may account for such a high risk of parasitic infection.
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| format | Article |
| id | doaj-art-65a2d54e36094cce9a2fac9121b60b21 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2013-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-65a2d54e36094cce9a2fac9121b60b212025-08-20T02:57:45ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802013-07-0170710.3855/jidc.2785Intestinal parasitic infection among the HIV-infected patients in NepalBishnu Raj Tiwari0Prakash Ghimire1Sarala Malla2Bimala Sharma3Surendra Karki4School of Health and Allied Science, Pokhara University, NepalCentral Department of Microbiology, Tribhuvan University, NepalNational Public Health Laboratory, Kathmandu, NepalGandaki Medical College, Tribhuvan University, NepalInfectious Disease Epidemiology Unit, Monash University, Melbourne, Australia Introduction: Intestinal parasitic infection has been a significant problem in HIV patients, worldwide. In this study, we aimed to measure the prevalence and identify the factors associated with intestinal parasitic infection in people infected with HIV and attending National Public Health Laboratory in Kathmandu, Nepal, for CD4 T-cell count. Methodology: An analytical cross-sectional study in 745 HIV-infected people attending for CD4 T-cell count was conducted. Results: The prevalence of intestinal parasitic infection was 22.4% (95% CI 19.5 to 25.5). In univariate analysis, age, sex, longer time since diagnosis of HIV, CD4 T-cell count of <200/µL, diarrhoea, marital status, and being under tuberculosis (TB) treatment were significantly associated with increased odds of intestinal parasite infection. However, in the logistic regression model, only the CD4 T-cell count of <200/µL (adjusted OR=4.2, 95% CI 2.5 to 7.0), diarrhoea (adjusted OR=2.8, 95% CI 1.8 to 4.3) and being under TB treatment (adjusted OR=2.9, 95% CI 1.8 to 4.6) remained as significant predictors. On stratification, CD4 T-cell count of <200/ µL was independently associated with higher odds of protozoal as well as helminthes infection. The parasites Cryptosporidium and Cyclospora were observed only in participants with CD4 T-cell counts <200/µL. Conclusions: Both protozoal and helminthic intestinal parasitic infections are common in HIV-infected people seeking care in healthcare facilities. The poor immune status as indicated by low CD4 T-cell count and TB may account for such a high risk of parasitic infection. https://jidc.org/index.php/journal/article/view/2785HIVintestinal parasiteCD4diarrhoea |
| spellingShingle | Bishnu Raj Tiwari Prakash Ghimire Sarala Malla Bimala Sharma Surendra Karki Intestinal parasitic infection among the HIV-infected patients in Nepal Journal of Infection in Developing Countries HIV intestinal parasite CD4 diarrhoea |
| title | Intestinal parasitic infection among the HIV-infected patients in Nepal |
| title_full | Intestinal parasitic infection among the HIV-infected patients in Nepal |
| title_fullStr | Intestinal parasitic infection among the HIV-infected patients in Nepal |
| title_full_unstemmed | Intestinal parasitic infection among the HIV-infected patients in Nepal |
| title_short | Intestinal parasitic infection among the HIV-infected patients in Nepal |
| title_sort | intestinal parasitic infection among the hiv infected patients in nepal |
| topic | HIV intestinal parasite CD4 diarrhoea |
| url | https://jidc.org/index.php/journal/article/view/2785 |
| work_keys_str_mv | AT bishnurajtiwari intestinalparasiticinfectionamongthehivinfectedpatientsinnepal AT prakashghimire intestinalparasiticinfectionamongthehivinfectedpatientsinnepal AT saralamalla intestinalparasiticinfectionamongthehivinfectedpatientsinnepal AT bimalasharma intestinalparasiticinfectionamongthehivinfectedpatientsinnepal AT surendrakarki intestinalparasiticinfectionamongthehivinfectedpatientsinnepal |