Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection

Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection

BackgroundThe role of regulatory CD8pos T cells (CD8pos Tregs) and cytotoxic CD8pos responder T cells (CD8pos Tresps) in maintaining stable graft function in kidney transplant recipients (KTR) remains largely unclear. The pathogenesis of graft deterioration in case of rejection involves the exhausti...

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Bibliographic Details
Main Authors: Florian Kälble, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
immunosuppressive therapy
rejection
CD8pos T cell differentiation
CD8pos responder T cells
CD8pos regulatory T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532086/full
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