Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C
Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The pres...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/703031 |
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| author | Hala O. El-Mesallamy Nadia M. Hamdy Hanan H. Rizk Abdel-Rahman El-Zayadi |
| author_facet | Hala O. El-Mesallamy Nadia M. Hamdy Hanan H. Rizk Abdel-Rahman El-Zayadi |
| author_sort | Hala O. El-Mesallamy |
| collection | DOAJ |
| description | Objective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) Egyptian patients and if associated with body mass index (BMI), IR, and tumor necrosis factor-alpha (TNF-α). Serum apelin levels were significantly higher in patients with CHC with median value (3.25) when compared with controls (1.11), at P<0.0001, with significant apelin variations among asymptomatic carriers (ASC), fibrosis, and cirrhosis patients, and also among obese and nonobese patients. Multiple regression analysis depicted that BMI, triglycerides, and total cholesterol were independent correlation factors to apelin levels, whereas TNF-α was found to be significantly negatively correlated to adjusted apelin in CHC patients (r=−0.5944, P<0.0001). IR was positively correlated to adjusted apelin in CHC patients (r=0.2663, P<0.05). Conclusion. Apelin level varies among stages of CHC, which may contribute to fibrosis progression. In addition, obesity and IR could act as comorbid factors affecting apelin level in patients with CHC. |
| format | Article |
| id | doaj-art-658db88b17b24d8ea203d61a51ee4663 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-658db88b17b24d8ea203d61a51ee46632025-02-03T01:02:09ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/703031703031Apelin Serum Level in Egyptian Patients with Chronic Hepatitis CHala O. El-Mesallamy0Nadia M. Hamdy1Hanan H. Rizk2Abdel-Rahman El-Zayadi3Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, EgyptBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, EgyptBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, EgyptTropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo 11566, EgyptObjective. Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) Egyptian patients and if associated with body mass index (BMI), IR, and tumor necrosis factor-alpha (TNF-α). Serum apelin levels were significantly higher in patients with CHC with median value (3.25) when compared with controls (1.11), at P<0.0001, with significant apelin variations among asymptomatic carriers (ASC), fibrosis, and cirrhosis patients, and also among obese and nonobese patients. Multiple regression analysis depicted that BMI, triglycerides, and total cholesterol were independent correlation factors to apelin levels, whereas TNF-α was found to be significantly negatively correlated to adjusted apelin in CHC patients (r=−0.5944, P<0.0001). IR was positively correlated to adjusted apelin in CHC patients (r=0.2663, P<0.05). Conclusion. Apelin level varies among stages of CHC, which may contribute to fibrosis progression. In addition, obesity and IR could act as comorbid factors affecting apelin level in patients with CHC.http://dx.doi.org/10.1155/2011/703031 |
| spellingShingle | Hala O. El-Mesallamy Nadia M. Hamdy Hanan H. Rizk Abdel-Rahman El-Zayadi Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C Mediators of Inflammation |
| title | Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C |
| title_full | Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C |
| title_fullStr | Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C |
| title_full_unstemmed | Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C |
| title_short | Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C |
| title_sort | apelin serum level in egyptian patients with chronic hepatitis c |
| url | http://dx.doi.org/10.1155/2011/703031 |
| work_keys_str_mv | AT halaoelmesallamy apelinserumlevelinegyptianpatientswithchronichepatitisc AT nadiamhamdy apelinserumlevelinegyptianpatientswithchronichepatitisc AT hananhrizk apelinserumlevelinegyptianpatientswithchronichepatitisc AT abdelrahmanelzayadi apelinserumlevelinegyptianpatientswithchronichepatitisc |