Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.)
Abstract Following a request from the European Commission, the EFSA was asked to deliver a scientific opinion on the proposed modification of the terms of the authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%), regarding the addition of a new product...
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| Language: | English |
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Wiley
2025-01-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2025.9133 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Maria Bastos Georges Bories Pier Sandro Cocconcelli Fernando Ramos Jaume Galobart Orsolya Holczknecht Paola Manini Alberto Navarro Villa Fabiola Pizzo Anna Dioni Maria Vittoria Vettori |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Maria Bastos Georges Bories Pier Sandro Cocconcelli Fernando Ramos Jaume Galobart Orsolya Holczknecht Paola Manini Alberto Navarro Villa Fabiola Pizzo Anna Dioni Maria Vittoria Vettori |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, the EFSA was asked to deliver a scientific opinion on the proposed modification of the terms of the authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%), regarding the addition of a new production route, by the yeast Yarrowia lipolytica CBS 146148 and to modify the additive specifications by substituting ethoxyquin by 4.4% butylated hydroxytoluene (BHT) and increasing the limit for dichloromethane to 80 mg/kg. The additive is already authorised as zootechnical feed additive for breeder hens. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded. CAROPHYLL® Red 10% containing canthaxanthin produced by fermentation with Yarrowia lipolytica CBS 146148 is safe for the target species, consumer and environment under the current authorised conditions of use for CAROPHYLL® Red 10%. Regarding user safety, canthaxanthin is not irritant to skin and eyes and unlikely to be a skin sensitiser. No conclusion can be reached on the respiratory sensitisation of canthaxanthin. In the absence of data with the additive CAROPHYLL® Red 10%, no conclusions can be reached regarding the safety of the additive for the user. CAROPHYLL® Red 10%, containing canthaxanthin produced by fermentation with Yarrowia lipolytica CBS 146148, is efficacious in breeder hens at 6 mg/kg complete feed. |
| format | Article |
| id | doaj-art-658bc1e2e7ac4b20b81e1929cfb549da |
| institution | Kabale University |
| issn | 1831-4732 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-658bc1e2e7ac4b20b81e1929cfb549da2025-01-31T12:06:04ZengWileyEFSA Journal1831-47322025-01-01231n/an/a10.2903/j.efsa.2025.9133Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Roberto Edoardo VillaGiovanna AzimontiEleftherios BonosHenrik ChristensenMojca DurjavaBirgit DusemundRonette GehringBoet GlandorfMaryline KoubaMarta López‐AlonsoFrancesca MarconCarlo NebbiaAlena PechováMiguel Prieto‐MaradonaIlen RöheKaterina TheodoridouMaria BastosGeorges BoriesPier Sandro CocconcelliFernando RamosJaume GalobartOrsolya HolczknechtPaola ManiniAlberto Navarro VillaFabiola PizzoAnna DioniMaria Vittoria VettoriAbstract Following a request from the European Commission, the EFSA was asked to deliver a scientific opinion on the proposed modification of the terms of the authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%), regarding the addition of a new production route, by the yeast Yarrowia lipolytica CBS 146148 and to modify the additive specifications by substituting ethoxyquin by 4.4% butylated hydroxytoluene (BHT) and increasing the limit for dichloromethane to 80 mg/kg. The additive is already authorised as zootechnical feed additive for breeder hens. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded. CAROPHYLL® Red 10% containing canthaxanthin produced by fermentation with Yarrowia lipolytica CBS 146148 is safe for the target species, consumer and environment under the current authorised conditions of use for CAROPHYLL® Red 10%. Regarding user safety, canthaxanthin is not irritant to skin and eyes and unlikely to be a skin sensitiser. No conclusion can be reached on the respiratory sensitisation of canthaxanthin. In the absence of data with the additive CAROPHYLL® Red 10%, no conclusions can be reached regarding the safety of the additive for the user. CAROPHYLL® Red 10%, containing canthaxanthin produced by fermentation with Yarrowia lipolytica CBS 146148, is efficacious in breeder hens at 6 mg/kg complete feed.https://doi.org/10.2903/j.efsa.2025.9133canthaxanthinCAROPHYLL® Red 10%efficacypoultry for breeding purposessafetyYarrowia lipolytica CBS 146148 |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Roberto Edoardo Villa Giovanna Azimonti Eleftherios Bonos Henrik Christensen Mojca Durjava Birgit Dusemund Ronette Gehring Boet Glandorf Maryline Kouba Marta López‐Alonso Francesca Marcon Carlo Nebbia Alena Pechová Miguel Prieto‐Maradona Ilen Röhe Katerina Theodoridou Maria Bastos Georges Bories Pier Sandro Cocconcelli Fernando Ramos Jaume Galobart Orsolya Holczknecht Paola Manini Alberto Navarro Villa Fabiola Pizzo Anna Dioni Maria Vittoria Vettori Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.) EFSA Journal canthaxanthin CAROPHYLL® Red 10% efficacy poultry for breeding purposes safety Yarrowia lipolytica CBS 146148 |
| title | Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.) |
| title_full | Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.) |
| title_fullStr | Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.) |
| title_full_unstemmed | Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.) |
| title_short | Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL® Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.) |
| title_sort | modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin carophyll r red 10 for breeder hens to include canthaxanthin produced with yarrowia lipolytica cbs 146148 dsm nutritional products ltd |
| topic | canthaxanthin CAROPHYLL® Red 10% efficacy poultry for breeding purposes safety Yarrowia lipolytica CBS 146148 |
| url | https://doi.org/10.2903/j.efsa.2025.9133 |
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