Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors
ObjectiveTo explore the influencing factors of recurrence after surgical treatment for early-stage cervical cancer (stages IA1-IIA1) and to investigate the relationship between human papillomavirus (HPV) infection and postoperative recurrence of lesions.MethodsA retrospective analysis was conducted...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1506521/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542375640039424 |
|---|---|
| author | Jing Na Ya Li Qiao Lu Yang Wang Shichao Han Jun Wang |
| author_facet | Jing Na Ya Li Qiao Lu Yang Wang Shichao Han Jun Wang |
| author_sort | Jing Na |
| collection | DOAJ |
| description | ObjectiveTo explore the influencing factors of recurrence after surgical treatment for early-stage cervical cancer (stages IA1-IIA1) and to investigate the relationship between human papillomavirus (HPV) infection and postoperative recurrence of lesions.MethodsA retrospective analysis was conducted on the clinical data of 242 patients who underwent surgical treatment for early-stage cervical cancer (FIGO stages IA1-IIA1) at the Second Affiliated Hospital of Dalian Medical University between 2015 and 2022. Cox regression analysis was employed to evaluate the relationship between persistent postoperative HPV infection and lesion vaginal local recurrence while identifying the associated risk factors for persistent HPV infection following surgery.ResultsWithin 12 months postoperatively, the HPV clearance rate was 88.11%. HPV infection persisted beyond 12 months in 19 patients (7.9%), with 3 cases demonstrating the same HPV genotypes (types 52, 58) as those identified preoperatively. Multivariate analysis identified persistent postoperative HPV infection (odds ratio [OR] 1.72, 95% confidence interval [CI] -1.14 to 5, p=0.001*) as an independent risk factor for recurrence. Additionally, smoking (OR 7.49, 95% CI 1.19 to 47.13, p=0.032), abnormal vaginal microbiota (OR 0.663, 95% CI 0.403 to 1.088, p=0.001*), and the type of surgical procedure (OR 0.32, 95% CI 0.11 to 0.91, p=0.033) were significantly associated with a higher rate of persistent HPV infection.ConclusionPersistent HPV infection after surgery is an independent risk factor for postoperative recurrence in early-stage cervical cancer. Surgical approach, abnormal vaginal microbiota, and smoking are associated factors for persistent HPV infection after surgery. |
| format | Article |
| id | doaj-art-657793e43bcd44b0ad8993ca2f2565bb |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-657793e43bcd44b0ad8993ca2f2565bb2025-02-04T05:28:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15065211506521Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factorsJing NaYa LiQiao LuYang WangShichao HanJun WangObjectiveTo explore the influencing factors of recurrence after surgical treatment for early-stage cervical cancer (stages IA1-IIA1) and to investigate the relationship between human papillomavirus (HPV) infection and postoperative recurrence of lesions.MethodsA retrospective analysis was conducted on the clinical data of 242 patients who underwent surgical treatment for early-stage cervical cancer (FIGO stages IA1-IIA1) at the Second Affiliated Hospital of Dalian Medical University between 2015 and 2022. Cox regression analysis was employed to evaluate the relationship between persistent postoperative HPV infection and lesion vaginal local recurrence while identifying the associated risk factors for persistent HPV infection following surgery.ResultsWithin 12 months postoperatively, the HPV clearance rate was 88.11%. HPV infection persisted beyond 12 months in 19 patients (7.9%), with 3 cases demonstrating the same HPV genotypes (types 52, 58) as those identified preoperatively. Multivariate analysis identified persistent postoperative HPV infection (odds ratio [OR] 1.72, 95% confidence interval [CI] -1.14 to 5, p=0.001*) as an independent risk factor for recurrence. Additionally, smoking (OR 7.49, 95% CI 1.19 to 47.13, p=0.032), abnormal vaginal microbiota (OR 0.663, 95% CI 0.403 to 1.088, p=0.001*), and the type of surgical procedure (OR 0.32, 95% CI 0.11 to 0.91, p=0.033) were significantly associated with a higher rate of persistent HPV infection.ConclusionPersistent HPV infection after surgery is an independent risk factor for postoperative recurrence in early-stage cervical cancer. Surgical approach, abnormal vaginal microbiota, and smoking are associated factors for persistent HPV infection after surgery.https://www.frontiersin.org/articles/10.3389/fonc.2025.1506521/fullHPV infectionscervical carcinomahysterectomyrecurrenceHPV - human papillomavirus |
| spellingShingle | Jing Na Ya Li Qiao Lu Yang Wang Shichao Han Jun Wang Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors Frontiers in Oncology HPV infections cervical carcinoma hysterectomy recurrence HPV - human papillomavirus |
| title | Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors |
| title_full | Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors |
| title_fullStr | Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors |
| title_full_unstemmed | Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors |
| title_short | Investigating the impact of persistent HPV infection on recurrence of lesions post-surgery for early-stage cervical cancer and related influencing factors |
| title_sort | investigating the impact of persistent hpv infection on recurrence of lesions post surgery for early stage cervical cancer and related influencing factors |
| topic | HPV infections cervical carcinoma hysterectomy recurrence HPV - human papillomavirus |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1506521/full |
| work_keys_str_mv | AT jingna investigatingtheimpactofpersistenthpvinfectiononrecurrenceoflesionspostsurgeryforearlystagecervicalcancerandrelatedinfluencingfactors AT yali investigatingtheimpactofpersistenthpvinfectiononrecurrenceoflesionspostsurgeryforearlystagecervicalcancerandrelatedinfluencingfactors AT qiaolu investigatingtheimpactofpersistenthpvinfectiononrecurrenceoflesionspostsurgeryforearlystagecervicalcancerandrelatedinfluencingfactors AT yangwang investigatingtheimpactofpersistenthpvinfectiononrecurrenceoflesionspostsurgeryforearlystagecervicalcancerandrelatedinfluencingfactors AT shichaohan investigatingtheimpactofpersistenthpvinfectiononrecurrenceoflesionspostsurgeryforearlystagecervicalcancerandrelatedinfluencingfactors AT junwang investigatingtheimpactofpersistenthpvinfectiononrecurrenceoflesionspostsurgeryforearlystagecervicalcancerandrelatedinfluencingfactors |