Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs
A study on florfenicol (FF) and florfenicol amine (FFA) residue depletion raws was conducted in eggs. After the chickens were administered successively florfenicol (FF) powder of 15 mg/kg (prevention group) and 30 mg/kg (treatment group) of body mass in the form of premix for 5 d, the eggs of each g...
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Zhejiang University Press
2021-01-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
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| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2020.03.241 |
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| author | ZHANG Jing ZHOU Qian GAO Yushi TANG Xiujun LU Junxian MA Lina CHEN Dawei TANG Mengjun |
| author_facet | ZHANG Jing ZHOU Qian GAO Yushi TANG Xiujun LU Junxian MA Lina CHEN Dawei TANG Mengjun |
| author_sort | ZHANG Jing |
| collection | DOAJ |
| description | A study on florfenicol (FF) and florfenicol amine (FFA) residue depletion raws was conducted in eggs. After the chickens were administered successively florfenicol (FF) powder of 15 mg/kg (prevention group) and 30 mg/kg (treatment group) of body mass in the form of premix for 5 d, the eggs of each group were collected at administration period and 1, 2, 3, 5, 7, 10, 12, 15, 18 d at withdrawal period. Then FF and FFA residues of egg, egg yolk and egg white were detected using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The results showed that the limits of detection (LOD) of FF and FFA in egg, egg yolk and egg white were 2 μg/kg, and the limits of quantitation (LOQ) were 5 μg/kg. The average recoveries were in the range of 78.9%-105.0% when the egg samples were added with FF in the range of 1.0-5.0 μg/kg, and the intraday precision and the interday precision was 2.22%-4.22% and 4.22%-6.54%, respectively. The peak values of FF residues (520.70, 797.12 μg/kg) of egg white in prevention group and treatment group, respectively, were higher than those of egg yolk (285.96, 442.40 μg/kg), while the peak values of FFA residue (218.40, 646.14 μg/kg) of egg yolk in prevention group and treatment group, respectively, were higher than those of egg white (87.36, 36.89 μg/kg). The elimination rates of FF and FFA in egg white were faster than those in egg yolk. FF and FFA residues and their total residues were positively correlated with the dosage. FF and FFA mainly existed in the egg yolk, and FF mainly existed in the egg white. The FF residual time of egg yolk in different dosage groups was 18 d. |
| format | Article |
| id | doaj-art-656c4a2d6fc84aa5b6ffd27d674bbdfd |
| institution | DOAJ |
| issn | 1008-9209 2097-5155 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Zhejiang University Press |
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| series | 浙江大学学报. 农业与生命科学版 |
| spelling | doaj-art-656c4a2d6fc84aa5b6ffd27d674bbdfd2025-08-20T02:47:40ZengZhejiang University Press浙江大学学报. 农业与生命科学版1008-92092097-51552021-01-014712713410.3785/j.issn.1008-9209.2020.03.24110089209Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggsZHANG JingZHOU QianGAO YushiTANG XiujunLU JunxianMA LinaCHEN DaweiTANG MengjunA study on florfenicol (FF) and florfenicol amine (FFA) residue depletion raws was conducted in eggs. After the chickens were administered successively florfenicol (FF) powder of 15 mg/kg (prevention group) and 30 mg/kg (treatment group) of body mass in the form of premix for 5 d, the eggs of each group were collected at administration period and 1, 2, 3, 5, 7, 10, 12, 15, 18 d at withdrawal period. Then FF and FFA residues of egg, egg yolk and egg white were detected using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The results showed that the limits of detection (LOD) of FF and FFA in egg, egg yolk and egg white were 2 μg/kg, and the limits of quantitation (LOQ) were 5 μg/kg. The average recoveries were in the range of 78.9%-105.0% when the egg samples were added with FF in the range of 1.0-5.0 μg/kg, and the intraday precision and the interday precision was 2.22%-4.22% and 4.22%-6.54%, respectively. The peak values of FF residues (520.70, 797.12 μg/kg) of egg white in prevention group and treatment group, respectively, were higher than those of egg yolk (285.96, 442.40 μg/kg), while the peak values of FFA residue (218.40, 646.14 μg/kg) of egg yolk in prevention group and treatment group, respectively, were higher than those of egg white (87.36, 36.89 μg/kg). The elimination rates of FF and FFA in egg white were faster than those in egg yolk. FF and FFA residues and their total residues were positively correlated with the dosage. FF and FFA mainly existed in the egg yolk, and FF mainly existed in the egg white. The FF residual time of egg yolk in different dosage groups was 18 d.https://www.academax.com/doi/10.3785/j.issn.1008-9209.2020.03.241florfenicolflorfenicol amineeggresidue depletionhigh performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) |
| spellingShingle | ZHANG Jing ZHOU Qian GAO Yushi TANG Xiujun LU Junxian MA Lina CHEN Dawei TANG Mengjun Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs 浙江大学学报. 农业与生命科学版 florfenicol florfenicol amine egg residue depletion high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) |
| title | Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs |
| title_full | Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs |
| title_fullStr | Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs |
| title_full_unstemmed | Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs |
| title_short | Residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs |
| title_sort | residue depletion laws of florfenicol and its metabolite florfenicol amine in eggs |
| topic | florfenicol florfenicol amine egg residue depletion high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) |
| url | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2020.03.241 |
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