Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study
Objectives: Acupuncture is a promising therapy for amnestic mild cognitive impairment (aMCI). Growing evidence suggest that alterations in the microbiota-gut-brain (MGB) axis contribute to the development and progression of aMCI. However, little is known about whether and how acupuncture change the...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Complementary Therapies in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229924001067 |
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| author | Zi-Han Yin Qiong-Nan Bao Ya-Qin Li Yi-Wei Liu Zi-Qi Wang Fang Ye Xia He Xin-Yue Zhang Wan-Qi Zhong Ke-Xin Wu Jin Yao Zi-Wen Chen Ling Zhao Fan-Rong Liang |
| author_facet | Zi-Han Yin Qiong-Nan Bao Ya-Qin Li Yi-Wei Liu Zi-Qi Wang Fang Ye Xia He Xin-Yue Zhang Wan-Qi Zhong Ke-Xin Wu Jin Yao Zi-Wen Chen Ling Zhao Fan-Rong Liang |
| author_sort | Zi-Han Yin |
| collection | DOAJ |
| description | Objectives: Acupuncture is a promising therapy for amnestic mild cognitive impairment (aMCI). Growing evidence suggest that alterations in the microbiota-gut-brain (MGB) axis contribute to the development and progression of aMCI. However, little is known about whether and how acupuncture change the MGB axis of aMCI individuals. Methods: This was a randomized, controlled, clinical trial. Forty patients with aMCI were randomly allocated to either the acupuncture group or the waitlist group. The primary outcome was the change in the Alzheimer’s Disease Assessment Scale-Cognitive Scale (ADAS-Cog) score. In addition, multi-omics was performed to detect changes in brain function, gut microbiota, and serum metabolites. Generalized estimating equations were used to estimate the outcomes, and correlational analyses were performed to explore the relationships between the clinical and multi-omics data. Results: Compared to a mean baseline to week 12 change of –3.94 in the acupuncture group, the mean change in the waitlist group was 1.72 (net difference, –5.66 [95 % CI, –6.98 to –4.35]). Compared to the waitlist group, acupuncture’s MGB axis modulatory effect exhibited altered the regional homogeneity values of Frontal_Med_Orb_L, Cingulum_Mid_L, and Frontal_Sup_Medial_L, relative abundance of gut Ruminococcus_sp_AF43_11 and s_Eubacterium_coprostanoligenes, and levels of serum (11E,15Z)-9,10,13-trihydroxyoctadeca-11,15-dienoic acid, dipropylene glycol dimethyl ether, N6-Me-dA, and DPK, which correlated with changes in ADAS-Cog scores. Conclusions: Our data imply that acupuncture ameliorates overall cognitive function, along with changes in brain activity, gut microbiota, and serum metabolites, providing preliminary evidence of the mechanisms acting through the MGB axis underlying the effects of acupuncture on aMCI. |
| format | Article |
| id | doaj-art-656489c6d0264b3d978684b71d924d13 |
| institution | Kabale University |
| issn | 0965-2299 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj-art-656489c6d0264b3d978684b71d924d132025-01-30T05:12:51ZengElsevierComplementary Therapies in Medicine0965-22992025-03-0188103118Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot studyZi-Han Yin0Qiong-Nan Bao1Ya-Qin Li2Yi-Wei Liu3Zi-Qi Wang4Fang Ye5Xia He6Xin-Yue Zhang7Wan-Qi Zhong8Ke-Xin Wu9Jin Yao10Zi-Wen Chen11Ling Zhao12Fan-Rong Liang13School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaThe West China Hospital, Chengdu, ChinaThe Fourth People’s Hospital of Chengdu, Chengdu, ChinaThe Sichuan Province People’s Hospital, Chengdu, ChinaThe Rehabilitation Hospital of Sichuan Province, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China; Correspondence to: School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, 37 Shierqiao Road, Chengdu, Sichuan 610075, ChinaSchool of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, China; Correspondence to: School of Acu-Mox and Tuina, Chengdu University of Traditional Chinese Medicine, 37 Shierqiao Road, Chengdu, Sichuan 610075, ChinaObjectives: Acupuncture is a promising therapy for amnestic mild cognitive impairment (aMCI). Growing evidence suggest that alterations in the microbiota-gut-brain (MGB) axis contribute to the development and progression of aMCI. However, little is known about whether and how acupuncture change the MGB axis of aMCI individuals. Methods: This was a randomized, controlled, clinical trial. Forty patients with aMCI were randomly allocated to either the acupuncture group or the waitlist group. The primary outcome was the change in the Alzheimer’s Disease Assessment Scale-Cognitive Scale (ADAS-Cog) score. In addition, multi-omics was performed to detect changes in brain function, gut microbiota, and serum metabolites. Generalized estimating equations were used to estimate the outcomes, and correlational analyses were performed to explore the relationships between the clinical and multi-omics data. Results: Compared to a mean baseline to week 12 change of –3.94 in the acupuncture group, the mean change in the waitlist group was 1.72 (net difference, –5.66 [95 % CI, –6.98 to –4.35]). Compared to the waitlist group, acupuncture’s MGB axis modulatory effect exhibited altered the regional homogeneity values of Frontal_Med_Orb_L, Cingulum_Mid_L, and Frontal_Sup_Medial_L, relative abundance of gut Ruminococcus_sp_AF43_11 and s_Eubacterium_coprostanoligenes, and levels of serum (11E,15Z)-9,10,13-trihydroxyoctadeca-11,15-dienoic acid, dipropylene glycol dimethyl ether, N6-Me-dA, and DPK, which correlated with changes in ADAS-Cog scores. Conclusions: Our data imply that acupuncture ameliorates overall cognitive function, along with changes in brain activity, gut microbiota, and serum metabolites, providing preliminary evidence of the mechanisms acting through the MGB axis underlying the effects of acupuncture on aMCI.http://www.sciencedirect.com/science/article/pii/S0965229924001067AcupunctureAmnestic mild cognitive impairmentRandomized controlled trialMicrobiota-gut-brain axisMulti-omics |
| spellingShingle | Zi-Han Yin Qiong-Nan Bao Ya-Qin Li Yi-Wei Liu Zi-Qi Wang Fang Ye Xia He Xin-Yue Zhang Wan-Qi Zhong Ke-Xin Wu Jin Yao Zi-Wen Chen Ling Zhao Fan-Rong Liang Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study Complementary Therapies in Medicine Acupuncture Amnestic mild cognitive impairment Randomized controlled trial Microbiota-gut-brain axis Multi-omics |
| title | Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study |
| title_full | Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study |
| title_fullStr | Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study |
| title_full_unstemmed | Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study |
| title_short | Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study |
| title_sort | discovery of the microbiota gut brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi omics analyses a pilot study |
| topic | Acupuncture Amnestic mild cognitive impairment Randomized controlled trial Microbiota-gut-brain axis Multi-omics |
| url | http://www.sciencedirect.com/science/article/pii/S0965229924001067 |
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