Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities
A series of 1-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3-chloro-4-(2-mercaptoquinolin-3-yl)azetidin-2-one (7a-j) have been synthesized from the condensation of aromatic amines with N-phenylacetamide. The thione nucleus formed from 2-chloroquionoline-3-carbadehyde using sodium sulphid...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/847180 |
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| author | Mallikarjunaswamy Chandrashekaraiah Mallesha Lingappa Vathsala Deepu Channe Gowda Doddamedur Giddegowda Bhadregowda |
| author_facet | Mallikarjunaswamy Chandrashekaraiah Mallesha Lingappa Vathsala Deepu Channe Gowda Doddamedur Giddegowda Bhadregowda |
| author_sort | Mallikarjunaswamy Chandrashekaraiah |
| collection | DOAJ |
| description | A series of 1-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3-chloro-4-(2-mercaptoquinolin-3-yl)azetidin-2-one (7a-j) have been synthesized from the condensation of aromatic amines with N-phenylacetamide. The thione nucleus formed from 2-chloroquionoline-3-carbadehyde using sodium sulphide in dimethyl formamide (DMF) was followed by the reaction with pyrimidine amine to form the Schiff base intermediates. Attempt has been made to derive final azetidinone analogues from Schiff bases by using chloroacetyl chloride. The newly synthesized analogues were examined for the antimicrobial activity against some bacterial and fungal strains and in vitro antituberculosis activity against mycobacterium tuberculosis. These observations provide some predictions to design further antibacterial and antituberculosis active compounds prior to their synthesis according to molecular studies. |
| format | Article |
| id | doaj-art-65611bec73774c13a7ce4b88578b8012 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-65611bec73774c13a7ce4b88578b80122025-02-03T01:08:00ZengWileyJournal of Chemistry2090-90632090-90712014-01-01201410.1155/2014/847180847180Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular ActivitiesMallikarjunaswamy Chandrashekaraiah0Mallesha Lingappa1Vathsala Deepu Channe Gowda2Doddamedur Giddegowda Bhadregowda3PG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 570025, IndiaPG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 570025, IndiaDepartment of Chemistry, Yuvaraja’s College, University of Mysore, Mysore 570005, IndiaDepartment of Chemistry, Yuvaraja’s College, University of Mysore, Mysore 570005, IndiaA series of 1-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3-chloro-4-(2-mercaptoquinolin-3-yl)azetidin-2-one (7a-j) have been synthesized from the condensation of aromatic amines with N-phenylacetamide. The thione nucleus formed from 2-chloroquionoline-3-carbadehyde using sodium sulphide in dimethyl formamide (DMF) was followed by the reaction with pyrimidine amine to form the Schiff base intermediates. Attempt has been made to derive final azetidinone analogues from Schiff bases by using chloroacetyl chloride. The newly synthesized analogues were examined for the antimicrobial activity against some bacterial and fungal strains and in vitro antituberculosis activity against mycobacterium tuberculosis. These observations provide some predictions to design further antibacterial and antituberculosis active compounds prior to their synthesis according to molecular studies.http://dx.doi.org/10.1155/2014/847180 |
| spellingShingle | Mallikarjunaswamy Chandrashekaraiah Mallesha Lingappa Vathsala Deepu Channe Gowda Doddamedur Giddegowda Bhadregowda Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities Journal of Chemistry |
| title | Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities |
| title_full | Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities |
| title_fullStr | Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities |
| title_full_unstemmed | Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities |
| title_short | Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities |
| title_sort | synthesis of some new pyrimidine azitidinone analogues and their antioxidant in vitro antimicrobial and antitubercular activities |
| url | http://dx.doi.org/10.1155/2014/847180 |
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